Effects of acetazolamide on the renal excretion of phosphate in hypoparathyroidism and pseudohypoparathyroidism

Tushar K. Sinha, Donald O. Allen, Sherry Queener, Norman H. Bell

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Studies were carried out in one patient with hypoparathyroidism (HP) and in eight patients with pseudohypoparathyroidism (PHP) to determine whether the diminished clearance of phosphate could be augmented by the diuretic acetazolamide, which had been reported from other laboratories to activate renal cortical adenylate cyclase in rats and to produce phosphaturia in parathyroidectomized dogs and rats. The effects of acetazolamide, 250 or 375 mg/day for 4 days, and of parathyroid extract (PTE), 6 Units/kg body weight per day for 4 days, on serum calcium and phosphate, phosphate clearance, urinary calcium, and urinary cyclic adenosine 3′,5′-monophosphate (cyclic AMP) were compared. Whereas PTE produced significant increases in mean urinary cyclic AMP and phosphate clearance in the patient with HP, it did not increase urinary cyclic AMP and increased phosphate clearance either very little or not at all in the patients with PHP. Acetazolamide significantly increased mean phosphate clearance in all patients without changing urinary cyclic AMP. Creatinine clearance was not increased by the drug in any of the patients. The diuretic significantly increased the mean serum calcium in each of the patients with PHP and lowered the mean serum phosphate when it was abnormally elevated in all of them. Urinary calcium was not consistently altered. It is concluded that acetazolamide in man produces modest phosphaturia. This effect is apparently not mediated by cyclic AMP.

Original languageEnglish
Pages (from-to)1188-1197
Number of pages10
JournalJournal of Laboratory and Clinical Medicine
Volume89
Issue number6
StatePublished - 1977

Fingerprint

Pseudohypoparathyroidism
Hypoparathyroidism
Acetazolamide
Phosphates
Adenosine
Familial Hypophosphatemia
Calcium
Diuretics
Adenosine Monophosphate
Rats
Serum
Adenylyl Cyclases
Renal Elimination
Creatinine
Cyclic AMP
Body Weight
Dogs
Kidney
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

Cite this

Effects of acetazolamide on the renal excretion of phosphate in hypoparathyroidism and pseudohypoparathyroidism. / Sinha, Tushar K.; Allen, Donald O.; Queener, Sherry; Bell, Norman H.

In: Journal of Laboratory and Clinical Medicine, Vol. 89, No. 6, 1977, p. 1188-1197.

Research output: Contribution to journalArticle

@article{84d0c4cfbb954bf29b8f6e2156a75039,
title = "Effects of acetazolamide on the renal excretion of phosphate in hypoparathyroidism and pseudohypoparathyroidism",
abstract = "Studies were carried out in one patient with hypoparathyroidism (HP) and in eight patients with pseudohypoparathyroidism (PHP) to determine whether the diminished clearance of phosphate could be augmented by the diuretic acetazolamide, which had been reported from other laboratories to activate renal cortical adenylate cyclase in rats and to produce phosphaturia in parathyroidectomized dogs and rats. The effects of acetazolamide, 250 or 375 mg/day for 4 days, and of parathyroid extract (PTE), 6 Units/kg body weight per day for 4 days, on serum calcium and phosphate, phosphate clearance, urinary calcium, and urinary cyclic adenosine 3′,5′-monophosphate (cyclic AMP) were compared. Whereas PTE produced significant increases in mean urinary cyclic AMP and phosphate clearance in the patient with HP, it did not increase urinary cyclic AMP and increased phosphate clearance either very little or not at all in the patients with PHP. Acetazolamide significantly increased mean phosphate clearance in all patients without changing urinary cyclic AMP. Creatinine clearance was not increased by the drug in any of the patients. The diuretic significantly increased the mean serum calcium in each of the patients with PHP and lowered the mean serum phosphate when it was abnormally elevated in all of them. Urinary calcium was not consistently altered. It is concluded that acetazolamide in man produces modest phosphaturia. This effect is apparently not mediated by cyclic AMP.",
author = "Sinha, {Tushar K.} and Allen, {Donald O.} and Sherry Queener and Bell, {Norman H.}",
year = "1977",
language = "English",
volume = "89",
pages = "1188--1197",
journal = "Translational Research",
issn = "1931-5244",
publisher = "Mosby Inc.",
number = "6",

}

TY - JOUR

T1 - Effects of acetazolamide on the renal excretion of phosphate in hypoparathyroidism and pseudohypoparathyroidism

AU - Sinha, Tushar K.

AU - Allen, Donald O.

AU - Queener, Sherry

AU - Bell, Norman H.

PY - 1977

Y1 - 1977

N2 - Studies were carried out in one patient with hypoparathyroidism (HP) and in eight patients with pseudohypoparathyroidism (PHP) to determine whether the diminished clearance of phosphate could be augmented by the diuretic acetazolamide, which had been reported from other laboratories to activate renal cortical adenylate cyclase in rats and to produce phosphaturia in parathyroidectomized dogs and rats. The effects of acetazolamide, 250 or 375 mg/day for 4 days, and of parathyroid extract (PTE), 6 Units/kg body weight per day for 4 days, on serum calcium and phosphate, phosphate clearance, urinary calcium, and urinary cyclic adenosine 3′,5′-monophosphate (cyclic AMP) were compared. Whereas PTE produced significant increases in mean urinary cyclic AMP and phosphate clearance in the patient with HP, it did not increase urinary cyclic AMP and increased phosphate clearance either very little or not at all in the patients with PHP. Acetazolamide significantly increased mean phosphate clearance in all patients without changing urinary cyclic AMP. Creatinine clearance was not increased by the drug in any of the patients. The diuretic significantly increased the mean serum calcium in each of the patients with PHP and lowered the mean serum phosphate when it was abnormally elevated in all of them. Urinary calcium was not consistently altered. It is concluded that acetazolamide in man produces modest phosphaturia. This effect is apparently not mediated by cyclic AMP.

AB - Studies were carried out in one patient with hypoparathyroidism (HP) and in eight patients with pseudohypoparathyroidism (PHP) to determine whether the diminished clearance of phosphate could be augmented by the diuretic acetazolamide, which had been reported from other laboratories to activate renal cortical adenylate cyclase in rats and to produce phosphaturia in parathyroidectomized dogs and rats. The effects of acetazolamide, 250 or 375 mg/day for 4 days, and of parathyroid extract (PTE), 6 Units/kg body weight per day for 4 days, on serum calcium and phosphate, phosphate clearance, urinary calcium, and urinary cyclic adenosine 3′,5′-monophosphate (cyclic AMP) were compared. Whereas PTE produced significant increases in mean urinary cyclic AMP and phosphate clearance in the patient with HP, it did not increase urinary cyclic AMP and increased phosphate clearance either very little or not at all in the patients with PHP. Acetazolamide significantly increased mean phosphate clearance in all patients without changing urinary cyclic AMP. Creatinine clearance was not increased by the drug in any of the patients. The diuretic significantly increased the mean serum calcium in each of the patients with PHP and lowered the mean serum phosphate when it was abnormally elevated in all of them. Urinary calcium was not consistently altered. It is concluded that acetazolamide in man produces modest phosphaturia. This effect is apparently not mediated by cyclic AMP.

UR - http://www.scopus.com/inward/record.url?scp=0017685341&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017685341&partnerID=8YFLogxK

M3 - Article

VL - 89

SP - 1188

EP - 1197

JO - Translational Research

JF - Translational Research

SN - 1931-5244

IS - 6

ER -