Effects of acute metabolic stress on striatal dopamine release in healthy volunteers

Caleb M. Adler, Igor Elman, Neil Weisenfeld, Lisa Kestler, David Pickar, Alan Breier

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Several lines of evidence indicate that a variety of metabolic stressors, including acute glucose deprivation are associated with dopamine release. Pharmacologic doses of the glucose analogue, 2-deoxyglucose (2DG) cause acute glucoprivation and are associated with enhanced dopamine turnover in preclinical studies. In this study, we utilized [11C]raclopride PET to examine 2DG-induced striatal dopamine release in healthy volunteers. Six healthy volunteers underwent PET scans involving assessment of 2DG-induced (40 mg/kg) decrements in striatal binding of the D2/D3 receptor radioligand [11C]raclopride. Decreases in [11C]raclopride specific binding reflect 2DG-induced changes in synaptic dopamine. Specific binding significantly decreased following 2DG administration, reflecting enhanced synaptic dopamine concentrations (p = .02). The administration of 2DG is associated with significant striatal dopamine release in healthy volunteers. Implications of these data for investigations of the role of stress in psychiatric disorders are discussed. Copyright (C) 2000 American College of Neuropsychopharmacology.

Original languageEnglish
Pages (from-to)545-550
Number of pages6
JournalNeuropsychopharmacology
Volume22
Issue number5
DOIs
StatePublished - May 2000

Fingerprint

Corpus Striatum
Physiological Stress
Deoxyglucose
Dopamine
Healthy Volunteers
Raclopride
Glucose
Positron-Emission Tomography
Psychiatry

Keywords

  • 2-Deoxyglucose
  • Dopamine
  • Glucoprivation
  • PET
  • Raclopride
  • Striatum

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of acute metabolic stress on striatal dopamine release in healthy volunteers. / Adler, Caleb M.; Elman, Igor; Weisenfeld, Neil; Kestler, Lisa; Pickar, David; Breier, Alan.

In: Neuropsychopharmacology, Vol. 22, No. 5, 05.2000, p. 545-550.

Research output: Contribution to journalArticle

Adler, Caleb M. ; Elman, Igor ; Weisenfeld, Neil ; Kestler, Lisa ; Pickar, David ; Breier, Alan. / Effects of acute metabolic stress on striatal dopamine release in healthy volunteers. In: Neuropsychopharmacology. 2000 ; Vol. 22, No. 5. pp. 545-550.
@article{2c6b2f6b9c1c4324b36ce3b49cecc1f1,
title = "Effects of acute metabolic stress on striatal dopamine release in healthy volunteers",
abstract = "Several lines of evidence indicate that a variety of metabolic stressors, including acute glucose deprivation are associated with dopamine release. Pharmacologic doses of the glucose analogue, 2-deoxyglucose (2DG) cause acute glucoprivation and are associated with enhanced dopamine turnover in preclinical studies. In this study, we utilized [11C]raclopride PET to examine 2DG-induced striatal dopamine release in healthy volunteers. Six healthy volunteers underwent PET scans involving assessment of 2DG-induced (40 mg/kg) decrements in striatal binding of the D2/D3 receptor radioligand [11C]raclopride. Decreases in [11C]raclopride specific binding reflect 2DG-induced changes in synaptic dopamine. Specific binding significantly decreased following 2DG administration, reflecting enhanced synaptic dopamine concentrations (p = .02). The administration of 2DG is associated with significant striatal dopamine release in healthy volunteers. Implications of these data for investigations of the role of stress in psychiatric disorders are discussed. Copyright (C) 2000 American College of Neuropsychopharmacology.",
keywords = "2-Deoxyglucose, Dopamine, Glucoprivation, PET, Raclopride, Striatum",
author = "Adler, {Caleb M.} and Igor Elman and Neil Weisenfeld and Lisa Kestler and David Pickar and Alan Breier",
year = "2000",
month = "5",
doi = "10.1016/S0893-133X(99)00153-0",
language = "English",
volume = "22",
pages = "545--550",
journal = "Neuropsychopharmacology",
issn = "0893-133X",
publisher = "Nature Publishing Group",
number = "5",

}

TY - JOUR

T1 - Effects of acute metabolic stress on striatal dopamine release in healthy volunteers

AU - Adler, Caleb M.

AU - Elman, Igor

AU - Weisenfeld, Neil

AU - Kestler, Lisa

AU - Pickar, David

AU - Breier, Alan

PY - 2000/5

Y1 - 2000/5

N2 - Several lines of evidence indicate that a variety of metabolic stressors, including acute glucose deprivation are associated with dopamine release. Pharmacologic doses of the glucose analogue, 2-deoxyglucose (2DG) cause acute glucoprivation and are associated with enhanced dopamine turnover in preclinical studies. In this study, we utilized [11C]raclopride PET to examine 2DG-induced striatal dopamine release in healthy volunteers. Six healthy volunteers underwent PET scans involving assessment of 2DG-induced (40 mg/kg) decrements in striatal binding of the D2/D3 receptor radioligand [11C]raclopride. Decreases in [11C]raclopride specific binding reflect 2DG-induced changes in synaptic dopamine. Specific binding significantly decreased following 2DG administration, reflecting enhanced synaptic dopamine concentrations (p = .02). The administration of 2DG is associated with significant striatal dopamine release in healthy volunteers. Implications of these data for investigations of the role of stress in psychiatric disorders are discussed. Copyright (C) 2000 American College of Neuropsychopharmacology.

AB - Several lines of evidence indicate that a variety of metabolic stressors, including acute glucose deprivation are associated with dopamine release. Pharmacologic doses of the glucose analogue, 2-deoxyglucose (2DG) cause acute glucoprivation and are associated with enhanced dopamine turnover in preclinical studies. In this study, we utilized [11C]raclopride PET to examine 2DG-induced striatal dopamine release in healthy volunteers. Six healthy volunteers underwent PET scans involving assessment of 2DG-induced (40 mg/kg) decrements in striatal binding of the D2/D3 receptor radioligand [11C]raclopride. Decreases in [11C]raclopride specific binding reflect 2DG-induced changes in synaptic dopamine. Specific binding significantly decreased following 2DG administration, reflecting enhanced synaptic dopamine concentrations (p = .02). The administration of 2DG is associated with significant striatal dopamine release in healthy volunteers. Implications of these data for investigations of the role of stress in psychiatric disorders are discussed. Copyright (C) 2000 American College of Neuropsychopharmacology.

KW - 2-Deoxyglucose

KW - Dopamine

KW - Glucoprivation

KW - PET

KW - Raclopride

KW - Striatum

UR - http://www.scopus.com/inward/record.url?scp=0034063223&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034063223&partnerID=8YFLogxK

U2 - 10.1016/S0893-133X(99)00153-0

DO - 10.1016/S0893-133X(99)00153-0

M3 - Article

VL - 22

SP - 545

EP - 550

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

SN - 0893-133X

IS - 5

ER -