Effects of age of pups and removal of existing litter on pup survival during cross-fostering between multiparous outbred mice

Debra L. Hickman, Melissa P. Swan

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Periparturient manipulation of mice is a valuable tool for modern research facilities. Although fostering and Caesarian section frequently are used to eradicate pathogens, an often overlooked use is to rescue poorly breeding strains of mice. Here we characterized the weaning success rates after fostering outbred pups of variable ages (younger than 24 h; 5 to 7 d; 10 to 12 d) with full or partial replacement of litters and multiparous dams. There were no significant differences between most groups when analyzed by full or partial replacement or age of donor pups as compared with control groups, in which pups were manipulated but returned to the birth dam or the birth dam was not disturbed. However, significant differences were associated with fostering of 10- to 12-d-old pups in combination with younger pups. Overall, these findings suggest that limiting fostering to pups that are within 48 h of age and age-matching litters when fostering are unnecessary.

Original languageEnglish (US)
Pages (from-to)641-646
Number of pages6
JournalJournal of the American Association for Laboratory Animal Science
Volume50
Issue number5
StatePublished - Sep 1 2011

ASJC Scopus subject areas

  • Animal Science and Zoology

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