Effects of angiotensin (1-7) upon right ventricular function in experimental rat pulmonary embolism

John A. Watts, Michael A. Gellar, Lori Stuart, Maria Obraztsova, Michael R. Marchick, Jeffrey A. Kline

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Right ventricular (RV) dysfunction contributes to poor clinical prognosis after pulmonary embolism (PE). The present studies evaluate the effects of angiotensin (1-7) (ANG (1-7)) upon RV function during experimental PE in rats. Circulating ANG II increased 8-fold 6 hr after PE (47±13 PE vs. 6±3 pg/mL, control, p<0.05). ACE2 protein was uniformly localized in the RV myocardium of control rats, but showed a patchy distribution with some cells devoid of stain after 6 or 18 hr of PE. RV function decreased 18 hr after PE compared with control treated animals (19±4 vs. 41±1 mmHg, respectively, p<0.05; 669±98 vs. 1354±77 mmHg/sec, respectively, p<0.05), while left ventricular function (LV) was not significantly changed. Animals treated with ANG (1-7) during PE showed improved RV +dP/dt and peak systolic pressure development to values not significantly different from control animals. Protection of RV function by ANG (1-7) was associated with improved arterial blood sO2, base excess and pH. Supplemental delivery of ANG (1-7) reduced the development of RV dysfunction, suggesting a novel approach to protecting RV function in the setting of acute experimental PE.

Original languageEnglish (US)
Pages (from-to)1287-1294
Number of pages8
JournalHistology and Histopathology
Volume26
Issue number10
StatePublished - Oct 1 2011
Externally publishedYes

Keywords

  • Angiotensin (1-7)
  • Angiotensin converting enzyme 2
  • Pulmonary embolism
  • Renin-angiotensin system
  • Right ventricle

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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    Watts, J. A., Gellar, M. A., Stuart, L., Obraztsova, M., Marchick, M. R., & Kline, J. A. (2011). Effects of angiotensin (1-7) upon right ventricular function in experimental rat pulmonary embolism. Histology and Histopathology, 26(10), 1287-1294.