Effects of aprindine HCl on cardiac tissues

V. Elharrar, P. R. Foster, D. P. Zipes

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Abstract

The effects of aprindine HCL on cardiac tissues were studied in anesthetized, open chest dogs pretreated with atropine (0.8 mg/kg) and propranolol (1.0 mg/kg). Aprindine (10-5-10-3 g/ml), injected into the sinus node artery, decreased the spontaneous sinus rate; when injected into the atrioventricular nodal artery, aprindine (10-4 g/ml) prolonged the conduction time and functional refractory period of the atrioventricular node. Intravenous administration of aprindine (1.4, 2.8 and 4.2 mg/kg cumulative dose) prolonged atrial and ventricular conduction time and prolonged the effective refractory period of both tissues. The results from this study indicate that aprindine has a negative dromotropic effect on all cardiac tissue.

Original languageEnglish (US)
Pages (from-to)201-205
Number of pages5
JournalJournal of Pharmacology and Experimental Therapeutics
Volume195
Issue number2
StatePublished - Dec 1 1975

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ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Elharrar, V., Foster, P. R., & Zipes, D. P. (1975). Effects of aprindine HCl on cardiac tissues. Journal of Pharmacology and Experimental Therapeutics, 195(2), 201-205.