Effects of aprindine HCl on slow channel action potentials and transient depolarizations in canine Purkinje fibers

V. Elharrar, J. C. Bailey, D. A. Lathrop, D. P. Zipes

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The electrophysiologic effects of aprindine hydrochloride were studied on normal Purkinje fibers, on Purkinje fibers superfused with Tyrode's solution containing 22 mM KCl and isoproterenol (1 x 10-5 M) and on transient depolarizations induced by exposure to acetylstrophanthidin (1.7-2 x 10-7 M). Aprindine (3 x 10-6 M) significantly reduces the action potential amplitude and dV/dt(max) and shortens the action potential duration but does not alter the resting membrane potential. Transient depolarizations were suppressed by aprindine at a dose of 2 x 10-6 M. Isoproterenol (1 x 10-5 M) failed to restore the transient depolarizations after suppression with aprindine. Slow responses induced in K-depolarized, isoproterenol-treated fibers were unchanged by aprindine (3 x 10-6-1 x 10-5 M) in the presence as well as in the absence of acetylstrophanthidin. These experiments suggest that aprindine does not have slow channel blocking properties and that an inward current through the slow channel cannot be considered as the sole basis of the digitalis-induced transient depolarization.

Original languageEnglish (US)
Pages (from-to)410-417
Number of pages8
JournalJournal of Pharmacology and Experimental Therapeutics
Volume205
Issue number2
StatePublished - Dec 1 1978

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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