Effects of atrial natriuretic factor on isolated arteries and perfused organs of trout

Kenneth Olson, K. D. Meisheri

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53 Citations (Scopus)

Abstract

Atrial natriuretic factor (ANF) increases blood pressure when injected into conscious trout [Duff and Olson, Am. J. Physiol. 251 (Regulatory Integrative Comp. Physiol. 20): R639-R642, 1986]. The effects and mechanisms of action of ANF on trout vessels in vitro were examined in the present study using isolated celiacomesenteric arterial rings, perfused gill arches, and a two-artery perfused trunk preparation. In all experiments, ANF alone either relaxed trout vessels or had no effect. ANF inhibited contractions of arterial rings produced by a variety of agonists in part through inhibition of intracellular calcium release. In perfused gills, ANF attenuated epinephrine (EPI) α-mediated vasoconstriction but had no effect on β-stimulated increases in water permeability. ANF only slightly lowered an EPI-induced increase in resistance in either pathway of the perfused trunk. These results indicate that the vascular effects and mechanism of action of ANF are similar in fish and mammals and that the pressor response to ANF injection in vivo is mediated through central or secondary effects.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume256
Issue number1
StatePublished - 1989

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Trout
Atrial Natriuretic Factor
Arteries
Epinephrine
Vasoconstriction
Blood Vessels
Mammals
Permeability
Fishes
Blood Pressure
Calcium
Injections
Water

ASJC Scopus subject areas

  • Physiology

Cite this

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