Effects of carnitine and atractyloside on canine cardiac electrical activity

R. F. Gilmour, E. S. Williams, B. B. Farmer, D. P. Zipes

Research output: Contribution to journalArticle

Abstract

It has been proposed that electrophysiological changes following coronary artery occlusion result from inhibition of the adenine nucleotide translocase and that these changes can be reduced by carnitine infusion or reproduced by infusion of K+-atractyloside. In the present study, we recorded bipolar electrograms during serial 3- to 5-min occlusions of the left anterior descending coronary artery in open-chest, anesthetized dogs. DL-Carnitine (100-200 mg/kg iv) prior to coronary artery occlusion did not significantly alter ischemia-induced electrogram changes. L-Carnitine (100 mg/min ia) distal to the site of occlusion during coronary artery occlusion partially reversed ischemia-induced electrogram changes, but these effects resembled those produced by intra-arterial infusion of NaCl. During normal perfusion, intra-arterial infusion of K+-atractyloside (750 μmol/10 min) or equimolar KCl produced similar reversible flattening of perfused zone electrograms. Sodium atractyloside (750 μmol/10 min ia) did not produce electrogram changes. We conclude that 1) carnitine does not attenuate ischemia-induced electrogram changes in this model and 2) K+-atractyloside-induced electrogram changes are primarily due to K+.

Original languageEnglish
Pages (from-to)505-512
Number of pages8
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume10
Issue number4
StatePublished - 1981

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Atractyloside
Carnitine
Canidae
Coronary Occlusion
Coronary Vessels
Intra Arterial Infusions
Ischemia
ATP Translocases Mitochondrial ADP
Thorax
Perfusion
Sodium
Dogs

ASJC Scopus subject areas

  • Physiology

Cite this

Effects of carnitine and atractyloside on canine cardiac electrical activity. / Gilmour, R. F.; Williams, E. S.; Farmer, B. B.; Zipes, D. P.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 10, No. 4, 1981, p. 505-512.

Research output: Contribution to journalArticle

Gilmour, R. F. ; Williams, E. S. ; Farmer, B. B. ; Zipes, D. P. / Effects of carnitine and atractyloside on canine cardiac electrical activity. In: American Journal of Physiology - Heart and Circulatory Physiology. 1981 ; Vol. 10, No. 4. pp. 505-512.
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