Effects of cell membrane disruption on the relaxation rates of blood and clot with various methemoglobin concentrations

James Bass, H. Dirk Sostman, Orest Boyko, J. A. Koepke

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The magnetic resonance imaging (MRI) characteristics of hemorrhage and clotted blood change with age. The effects of methemoglobin and cell membrane lysis, factors which in part may underlie this evolution of imaging characteristics, were studied using clotted and heparinized dog blood at various methemoglobin concentrations. Cell lysis did not alter the longitudinal relaxation rate (1/T1) in clotted or unclotted samples. Membrane lysis altered significantly the transverse relaxation rate (1/T2) in both clotted and unclotted samples. Lysed samples of oxygenated blood at 0% methemoglobin had significantly higher T2 values than intact samples. At 0% methemoglobin, clotted samples had slightly but significantly shorter relaxation times than unclotted samples. Within the samples studied, large changes in the state of oxygenation and methemoglobin content were observed in less than 24 h. Such changes necessitate frequent monitoring of these parameters if serial studies are to be done.

Original languageEnglish (US)
Pages (from-to)1232-1237
Number of pages6
JournalInvestigative Radiology
Volume25
Issue number11
DOIs
StatePublished - Nov 1990

Keywords

  • Blood
  • Clot
  • Magnetic resonance
  • Membrane lysis
  • Methemoglobin

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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