Effects of circulating IGF-I on glucose and amino acid kinetics in the ovine fetus

Edward A. Liechty, David W. Boyle, Helen Moorehead, Wei Hua Lee, Ronald R. Bowsher, Scott C. Denne

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To investigate the role of insulin-like growth factor I (IGF-I) in the regulation of fetal metabolism, the kinetics of leucine, phenylalanine, and glucose were assessed in the chronically catheterized ovine fetus (0.85 gestation) before and during infusion of recombinant human IGF-I (rhIGF-I). Substrate kinetics were determined by tracer dilution. rhIGF-I was infused at 6.7 nmol-kg fetus-1 · h-1. Fetal insulin and growth hormone concentrations were significantly decreased by 50% during rhIGF-I infusion. Net umbilical glucose uptake was unchanged, and glucose rate of appearance increased in the fed state only. There were no changes in the net umbilical uptakes of leucine or phenylalanine, but the rates of appearance of both declined during rhIGF-I infusion, indicative of decreased fetal protein breakdown (Ra, Leu 45.4 ±1.40 to 40 ±1.4 umol/min in the fed state, 43 ±1.5 to 37 ±1.5 umol/min in the fasted state; Rajphe 10.7 ±0.3 to 10.4 ±0.3 umol/min in the fed state and from 10.7 ±0.3 to 9.8 ±0.3 umol/min in the fasted state). Leucine oxidation was also decreased (8.90 ±0.76 to 6.52 ±0.81 jimol/min, P = 0.025), more so in the fasted than the fed state. These results indicate a significant antiproteolytic endocrine effect for IGF-I in the late-gestation mammalian fetus.

Original languageEnglish (US)
Pages (from-to)E186-E191
JournalAmerican Journal of Physiology
Volume271
Issue number1 PART 1
StatePublished - Dec 1 1996

Fingerprint

Insulin-Like Growth Factor I
Sheep
Fetus
Amino Acids
Glucose
Leucine
Umbilicus
Phenylalanine
Fetal Proteins
Pregnancy
Fetal Development
Growth Hormone
Insulin

Keywords

  • Growth hormone
  • Insulin
  • Insulin-like growth factor i
  • Leucine
  • Phenylalanine
  • Somatostatin

ASJC Scopus subject areas

  • Physiology (medical)

Cite this

Liechty, E. A., Boyle, D. W., Moorehead, H., Lee, W. H., Bowsher, R. R., & Denne, S. C. (1996). Effects of circulating IGF-I on glucose and amino acid kinetics in the ovine fetus. American Journal of Physiology, 271(1 PART 1), E186-E191.

Effects of circulating IGF-I on glucose and amino acid kinetics in the ovine fetus. / Liechty, Edward A.; Boyle, David W.; Moorehead, Helen; Lee, Wei Hua; Bowsher, Ronald R.; Denne, Scott C.

In: American Journal of Physiology, Vol. 271, No. 1 PART 1, 01.12.1996, p. E186-E191.

Research output: Contribution to journalArticle

Liechty, EA, Boyle, DW, Moorehead, H, Lee, WH, Bowsher, RR & Denne, SC 1996, 'Effects of circulating IGF-I on glucose and amino acid kinetics in the ovine fetus', American Journal of Physiology, vol. 271, no. 1 PART 1, pp. E186-E191.
Liechty, Edward A. ; Boyle, David W. ; Moorehead, Helen ; Lee, Wei Hua ; Bowsher, Ronald R. ; Denne, Scott C. / Effects of circulating IGF-I on glucose and amino acid kinetics in the ovine fetus. In: American Journal of Physiology. 1996 ; Vol. 271, No. 1 PART 1. pp. E186-E191.
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