Effects of cyclophotocoagulation with a neodymium

yttrium-aluminum-garnet laser on corneal sensitivity, intraocular pressure, aqueous tear production, and corneal nerve morphology in eyes of dogs

Anne Kelley Weigt, Ian P. Herring, Carl Marfurt, J. Phillip Pickett, Robert B. Duncan, Daniel L. Ward

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective-To determine effects of cyclophotocoagulation via administration of 100 J with a neodymium:yttrium aluminum garnet (Nd:YAG) laser on corneal touch threshold (CTT), intraocular pressure (IOP), aqueous tear production, and corneal nerve morphology in eyes of dogs. Animals-15 dogs. Procedure-Noncontact Nd:YAG laser was transsclerally applied (10 applications; 25 W for 0.1 seconds for each application to each of 4 quadrants) to the ciliary body of the left eye of 15 dogs; the right eye was the control eye. Corneal integrity, CTT, tear production as measured by the Schirmer tear test (STT), and IOP were evaluated for 14 days following laser treatment. On day 14, dogs were euthanatized, eyes harvested, and corneas stained with gold chloride. Major nerve bundles were analyzed by use of a drawing tube attached to a light microscope, and maximum diameters were measured by use of image analysis software. Results-All laser treated eyes had significantly higher CTT values, compared with control eyes. Six of 15 laser-treated eyes developed ulcerative keratitis. On most days, IOP was significantly lower in laser-treated eyes in both morning and evening. Laser-treated eyes had a significant decrease of approximately 1 nerve bundle/corneal quadrant. Values for STT or nerve bundle diameters did not differ significantly. Conclusions and Clinical Relevance-Administration of 100 J with a Nd:YAG laser effectively reduced IOP while increasing CTT and caused a significant decrease in number, but not diameter, of major corneal nerve bundles. Nerve damage and corneal hypoesthesia are etiologic factors in ulcerative keratitis following Nd:YAG cyclophotocoagulation.

Original languageEnglish (US)
Pages (from-to)906-915
Number of pages10
JournalAmerican Journal of Veterinary Research
Volume63
Issue number6
StatePublished - 2002
Externally publishedYes

Fingerprint

neodymium
yttrium
Neodymium
Solid-State Lasers
Tears
Intraocular Pressure
lasers
aluminum
nerve tissue
eyes
Dogs
dogs
touch (sensation)
Touch
Lasers
water
Corneal Ulcer
keratitis
Ciliary Body
Hypesthesia

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Effects of cyclophotocoagulation with a neodymium : yttrium-aluminum-garnet laser on corneal sensitivity, intraocular pressure, aqueous tear production, and corneal nerve morphology in eyes of dogs. / Weigt, Anne Kelley; Herring, Ian P.; Marfurt, Carl; Pickett, J. Phillip; Duncan, Robert B.; Ward, Daniel L.

In: American Journal of Veterinary Research, Vol. 63, No. 6, 2002, p. 906-915.

Research output: Contribution to journalArticle

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abstract = "Objective-To determine effects of cyclophotocoagulation via administration of 100 J with a neodymium:yttrium aluminum garnet (Nd:YAG) laser on corneal touch threshold (CTT), intraocular pressure (IOP), aqueous tear production, and corneal nerve morphology in eyes of dogs. Animals-15 dogs. Procedure-Noncontact Nd:YAG laser was transsclerally applied (10 applications; 25 W for 0.1 seconds for each application to each of 4 quadrants) to the ciliary body of the left eye of 15 dogs; the right eye was the control eye. Corneal integrity, CTT, tear production as measured by the Schirmer tear test (STT), and IOP were evaluated for 14 days following laser treatment. On day 14, dogs were euthanatized, eyes harvested, and corneas stained with gold chloride. Major nerve bundles were analyzed by use of a drawing tube attached to a light microscope, and maximum diameters were measured by use of image analysis software. Results-All laser treated eyes had significantly higher CTT values, compared with control eyes. Six of 15 laser-treated eyes developed ulcerative keratitis. On most days, IOP was significantly lower in laser-treated eyes in both morning and evening. Laser-treated eyes had a significant decrease of approximately 1 nerve bundle/corneal quadrant. Values for STT or nerve bundle diameters did not differ significantly. Conclusions and Clinical Relevance-Administration of 100 J with a Nd:YAG laser effectively reduced IOP while increasing CTT and caused a significant decrease in number, but not diameter, of major corneal nerve bundles. Nerve damage and corneal hypoesthesia are etiologic factors in ulcerative keratitis following Nd:YAG cyclophotocoagulation.",
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