Effects of exercise training on smooth muscle relaxation and myoplasmic free Ca 2+ (Ca m) responses of coronary arteries distal to chronic occlusion

C. L. Heaps, J. A. Rapps, Q. Zhong, Michael Sturek, M. H. Laughlin, J. L. Parker

Research output: Contribution to journalArticle

Abstract

We evaluated combined effects of chronic coronary occlusion and exercise training on vasodilator responsiveness of coronary artery rings (1.0-2.5 mm OD) isolated from sedentary (SED; pen-confined) or exercise-trained (EX; treadmill run, 5 days/wk for 16-20 wk) Yucatan miniature swine. Ameroid occluders were surgically placed on the proximal left circumflex coronary artery (LCX) 8 weeks prior to SED or EX protocols. In SED animals (n=10), relaxation responses to adenosine (ADO;10 -8 to 10 -3 M), but not nitroprusside (NP;10 -10 to 10 -4 M), were significantly (Pm measures were impaired in LCX vs LAD arteries isolated from SED, but not EX animals. Preliminary studies (n=5) suggest that relaxation to the β-adrenergic agonist, isoproterenol, (ISO; 10 -9 to 10 -6 M) was impaired in LCX vs. LAD arteries, but unlike ADO, ISO-induced relaxation remained impaired in EX animals. Our data suggest exercise corrects impaired ADO-mediated relaxation and Ca m responses associated with chronic coronary occlusion; mechanisms may involve receptor-specific and/or second-messenger (cAMP vs cGMP) pathways.

Original languageEnglish (US)
JournalFASEB Journal
Volume11
Issue number3
StatePublished - 1997
Externally publishedYes

Fingerprint

Muscle Relaxation
coronary vessels
smooth muscle
Smooth Muscle
Muscle
Coronary Vessels
Animals
exercise
Coronary Occlusion
Exercise
arteries
Arteries
adrenergic agonists
Miniature Swine
miniature swine
Exercise equipment
animals
Adrenergic Agonists
vasodilator agents
second messengers

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Effects of exercise training on smooth muscle relaxation and myoplasmic free Ca 2+ (Ca m) responses of coronary arteries distal to chronic occlusion. / Heaps, C. L.; Rapps, J. A.; Zhong, Q.; Sturek, Michael; Laughlin, M. H.; Parker, J. L.

In: FASEB Journal, Vol. 11, No. 3, 1997.

Research output: Contribution to journalArticle

@article{8403f9911e8141238a759beca260447e,
title = "Effects of exercise training on smooth muscle relaxation and myoplasmic free Ca 2+ (Ca m) responses of coronary arteries distal to chronic occlusion",
abstract = "We evaluated combined effects of chronic coronary occlusion and exercise training on vasodilator responsiveness of coronary artery rings (1.0-2.5 mm OD) isolated from sedentary (SED; pen-confined) or exercise-trained (EX; treadmill run, 5 days/wk for 16-20 wk) Yucatan miniature swine. Ameroid occluders were surgically placed on the proximal left circumflex coronary artery (LCX) 8 weeks prior to SED or EX protocols. In SED animals (n=10), relaxation responses to adenosine (ADO;10 -8 to 10 -3 M), but not nitroprusside (NP;10 -10 to 10 -4 M), were significantly (Pm measures were impaired in LCX vs LAD arteries isolated from SED, but not EX animals. Preliminary studies (n=5) suggest that relaxation to the β-adrenergic agonist, isoproterenol, (ISO; 10 -9 to 10 -6 M) was impaired in LCX vs. LAD arteries, but unlike ADO, ISO-induced relaxation remained impaired in EX animals. Our data suggest exercise corrects impaired ADO-mediated relaxation and Ca m responses associated with chronic coronary occlusion; mechanisms may involve receptor-specific and/or second-messenger (cAMP vs cGMP) pathways.",
author = "Heaps, {C. L.} and Rapps, {J. A.} and Q. Zhong and Michael Sturek and Laughlin, {M. H.} and Parker, {J. L.}",
year = "1997",
language = "English (US)",
volume = "11",
journal = "FASEB Journal",
issn = "0892-6638",
publisher = "FASEB",
number = "3",

}

TY - JOUR

T1 - Effects of exercise training on smooth muscle relaxation and myoplasmic free Ca 2+ (Ca m) responses of coronary arteries distal to chronic occlusion

AU - Heaps, C. L.

AU - Rapps, J. A.

AU - Zhong, Q.

AU - Sturek, Michael

AU - Laughlin, M. H.

AU - Parker, J. L.

PY - 1997

Y1 - 1997

N2 - We evaluated combined effects of chronic coronary occlusion and exercise training on vasodilator responsiveness of coronary artery rings (1.0-2.5 mm OD) isolated from sedentary (SED; pen-confined) or exercise-trained (EX; treadmill run, 5 days/wk for 16-20 wk) Yucatan miniature swine. Ameroid occluders were surgically placed on the proximal left circumflex coronary artery (LCX) 8 weeks prior to SED or EX protocols. In SED animals (n=10), relaxation responses to adenosine (ADO;10 -8 to 10 -3 M), but not nitroprusside (NP;10 -10 to 10 -4 M), were significantly (Pm measures were impaired in LCX vs LAD arteries isolated from SED, but not EX animals. Preliminary studies (n=5) suggest that relaxation to the β-adrenergic agonist, isoproterenol, (ISO; 10 -9 to 10 -6 M) was impaired in LCX vs. LAD arteries, but unlike ADO, ISO-induced relaxation remained impaired in EX animals. Our data suggest exercise corrects impaired ADO-mediated relaxation and Ca m responses associated with chronic coronary occlusion; mechanisms may involve receptor-specific and/or second-messenger (cAMP vs cGMP) pathways.

AB - We evaluated combined effects of chronic coronary occlusion and exercise training on vasodilator responsiveness of coronary artery rings (1.0-2.5 mm OD) isolated from sedentary (SED; pen-confined) or exercise-trained (EX; treadmill run, 5 days/wk for 16-20 wk) Yucatan miniature swine. Ameroid occluders were surgically placed on the proximal left circumflex coronary artery (LCX) 8 weeks prior to SED or EX protocols. In SED animals (n=10), relaxation responses to adenosine (ADO;10 -8 to 10 -3 M), but not nitroprusside (NP;10 -10 to 10 -4 M), were significantly (Pm measures were impaired in LCX vs LAD arteries isolated from SED, but not EX animals. Preliminary studies (n=5) suggest that relaxation to the β-adrenergic agonist, isoproterenol, (ISO; 10 -9 to 10 -6 M) was impaired in LCX vs. LAD arteries, but unlike ADO, ISO-induced relaxation remained impaired in EX animals. Our data suggest exercise corrects impaired ADO-mediated relaxation and Ca m responses associated with chronic coronary occlusion; mechanisms may involve receptor-specific and/or second-messenger (cAMP vs cGMP) pathways.

UR - http://www.scopus.com/inward/record.url?scp=33750272424&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750272424&partnerID=8YFLogxK

M3 - Article

VL - 11

JO - FASEB Journal

JF - FASEB Journal

SN - 0892-6638

IS - 3

ER -