Effects of fluoxetine on the intragastric self-administration of ethanol in the alcohol preferring P line of rats

J. M. Murphy, M. B. Waller, G. J. Gatto, W. J. McBride, L. Lumeng, T. K. Li

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Rats of the alcohol-preferring P line (n=7) were trained to self-administer ethanol (20% v/v) and water via an intragastric IG catheter. Food was available ad lib. Ethanol intakes averaged approximately 5-6 g/kg body wt./day. Treatment with the serotonin (5-HT) uptake inhibitor fluoxetine (10 mg/kg/day; IG) for seven consecutive days produced a marked decrease in ethanol self-administration on the first day, which was sustained throughout the seven days of treatment to values as low as 1 g/kg/day. Concomitant with the decrease in ethanol intake, the self-infusion of water gradually increased during the period of fluoxetine treatment. Total caloric intake (ethanol plus food) was moderately reduced during fluoxetine treatment; the decrease in food consumption was consistent but not statistically significant. When fluoxetine treatment was terminated, ethanol self-administration quickly returned to the prefluoxetine levels, while water intake began to decrease. Since no ethanol was consumed orally, the IG ethanol was not self-administered for its taste or smell, but apparently for its postingestive pharmacological effects. The robust reduction of ethanol self-infusion that occurred with fluoxetine treatment suggests that the 5-HT systems are involved in the reinforcing effects of ethanol in the P line of rats.

Original languageEnglish
Pages (from-to)283-286
Number of pages4
JournalAlcohol
Volume5
Issue number4
DOIs
StatePublished - 1988

Fingerprint

self-administration
Self Administration
Fluoxetine
Rats
Ethanol
alcohol
Alcohols
water
food
food consumption
Food
Serotonin
Therapeutics
Values
Water
Smell
Catheters
Serotonin Uptake Inhibitors
Water levels
Energy Intake

Keywords

  • Alcohol-preferring rats
  • Ethanol intake
  • Fluoxetine
  • Intragastric self-administration

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Neuroscience(all)
  • Behavioral Neuroscience
  • Toxicology
  • Health(social science)

Cite this

Murphy, J. M., Waller, M. B., Gatto, G. J., McBride, W. J., Lumeng, L., & Li, T. K. (1988). Effects of fluoxetine on the intragastric self-administration of ethanol in the alcohol preferring P line of rats. Alcohol, 5(4), 283-286. https://doi.org/10.1016/0741-8329(88)90066-3

Effects of fluoxetine on the intragastric self-administration of ethanol in the alcohol preferring P line of rats. / Murphy, J. M.; Waller, M. B.; Gatto, G. J.; McBride, W. J.; Lumeng, L.; Li, T. K.

In: Alcohol, Vol. 5, No. 4, 1988, p. 283-286.

Research output: Contribution to journalArticle

Murphy, J. M. ; Waller, M. B. ; Gatto, G. J. ; McBride, W. J. ; Lumeng, L. ; Li, T. K. / Effects of fluoxetine on the intragastric self-administration of ethanol in the alcohol preferring P line of rats. In: Alcohol. 1988 ; Vol. 5, No. 4. pp. 283-286.
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