Effects of hypothermia on brainstem auditory evoked potentials in humans

Omkar Markand, B. I. Lee, C. Warren, R. K. Stoelting, R. D. King, John Brown, Y. Mahomed

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Ten adult patients who underwent open heart surgery under induced hypothermia had brainstem auditory evoked potentials (BAEPs) recorded at 1°- to 2°C-steps as body temperature was lowered from 36°C to 20°C to determine temperature-dependent changes. Hypothermia produced increased latencies of BAEP waves I, III, and V; the prolongation was more severe for the later components with the results that interpeak latencies I-III, III-V, and I-V were also prolonged. The temperature-latency relationship was nonlinear and best expressed by exponential curve. The latencies of waves I, III, V and the interpeak latency I-V increased roughly 7% for each 1°C drop; they doubled at a temperature around 26°C. The amplitude of the BAEP components had a quasiparabolic relationship to temperature; the amplitude rose with hypothermia to 28° or 27°C, but decreased linearly with further cooling. All BAEP components were present at temperatures above 23°C and absent below 20°C. With rewarming, the changes reversed and BAEPs returned to initial prehypothermia status.

Original languageEnglish
Pages (from-to)507-513
Number of pages7
JournalAnnals of Neurology
Volume22
Issue number4
StatePublished - 1987

Fingerprint

Brain Stem Auditory Evoked Potentials
Hypothermia
Temperature
Induced Hypothermia
Rewarming
Body Temperature
Thoracic Surgery

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Markand, O., Lee, B. I., Warren, C., Stoelting, R. K., King, R. D., Brown, J., & Mahomed, Y. (1987). Effects of hypothermia on brainstem auditory evoked potentials in humans. Annals of Neurology, 22(4), 507-513.

Effects of hypothermia on brainstem auditory evoked potentials in humans. / Markand, Omkar; Lee, B. I.; Warren, C.; Stoelting, R. K.; King, R. D.; Brown, John; Mahomed, Y.

In: Annals of Neurology, Vol. 22, No. 4, 1987, p. 507-513.

Research output: Contribution to journalArticle

Markand, O, Lee, BI, Warren, C, Stoelting, RK, King, RD, Brown, J & Mahomed, Y 1987, 'Effects of hypothermia on brainstem auditory evoked potentials in humans', Annals of Neurology, vol. 22, no. 4, pp. 507-513.
Markand, Omkar ; Lee, B. I. ; Warren, C. ; Stoelting, R. K. ; King, R. D. ; Brown, John ; Mahomed, Y. / Effects of hypothermia on brainstem auditory evoked potentials in humans. In: Annals of Neurology. 1987 ; Vol. 22, No. 4. pp. 507-513.
@article{7eeba0287aed47d1b026d1350a59dd8c,
title = "Effects of hypothermia on brainstem auditory evoked potentials in humans",
abstract = "Ten adult patients who underwent open heart surgery under induced hypothermia had brainstem auditory evoked potentials (BAEPs) recorded at 1°- to 2°C-steps as body temperature was lowered from 36°C to 20°C to determine temperature-dependent changes. Hypothermia produced increased latencies of BAEP waves I, III, and V; the prolongation was more severe for the later components with the results that interpeak latencies I-III, III-V, and I-V were also prolonged. The temperature-latency relationship was nonlinear and best expressed by exponential curve. The latencies of waves I, III, V and the interpeak latency I-V increased roughly 7{\%} for each 1°C drop; they doubled at a temperature around 26°C. The amplitude of the BAEP components had a quasiparabolic relationship to temperature; the amplitude rose with hypothermia to 28° or 27°C, but decreased linearly with further cooling. All BAEP components were present at temperatures above 23°C and absent below 20°C. With rewarming, the changes reversed and BAEPs returned to initial prehypothermia status.",
author = "Omkar Markand and Lee, {B. I.} and C. Warren and Stoelting, {R. K.} and King, {R. D.} and John Brown and Y. Mahomed",
year = "1987",
language = "English",
volume = "22",
pages = "507--513",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Effects of hypothermia on brainstem auditory evoked potentials in humans

AU - Markand, Omkar

AU - Lee, B. I.

AU - Warren, C.

AU - Stoelting, R. K.

AU - King, R. D.

AU - Brown, John

AU - Mahomed, Y.

PY - 1987

Y1 - 1987

N2 - Ten adult patients who underwent open heart surgery under induced hypothermia had brainstem auditory evoked potentials (BAEPs) recorded at 1°- to 2°C-steps as body temperature was lowered from 36°C to 20°C to determine temperature-dependent changes. Hypothermia produced increased latencies of BAEP waves I, III, and V; the prolongation was more severe for the later components with the results that interpeak latencies I-III, III-V, and I-V were also prolonged. The temperature-latency relationship was nonlinear and best expressed by exponential curve. The latencies of waves I, III, V and the interpeak latency I-V increased roughly 7% for each 1°C drop; they doubled at a temperature around 26°C. The amplitude of the BAEP components had a quasiparabolic relationship to temperature; the amplitude rose with hypothermia to 28° or 27°C, but decreased linearly with further cooling. All BAEP components were present at temperatures above 23°C and absent below 20°C. With rewarming, the changes reversed and BAEPs returned to initial prehypothermia status.

AB - Ten adult patients who underwent open heart surgery under induced hypothermia had brainstem auditory evoked potentials (BAEPs) recorded at 1°- to 2°C-steps as body temperature was lowered from 36°C to 20°C to determine temperature-dependent changes. Hypothermia produced increased latencies of BAEP waves I, III, and V; the prolongation was more severe for the later components with the results that interpeak latencies I-III, III-V, and I-V were also prolonged. The temperature-latency relationship was nonlinear and best expressed by exponential curve. The latencies of waves I, III, V and the interpeak latency I-V increased roughly 7% for each 1°C drop; they doubled at a temperature around 26°C. The amplitude of the BAEP components had a quasiparabolic relationship to temperature; the amplitude rose with hypothermia to 28° or 27°C, but decreased linearly with further cooling. All BAEP components were present at temperatures above 23°C and absent below 20°C. With rewarming, the changes reversed and BAEPs returned to initial prehypothermia status.

UR - http://www.scopus.com/inward/record.url?scp=0023616212&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023616212&partnerID=8YFLogxK

M3 - Article

VL - 22

SP - 507

EP - 513

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 4

ER -