Effects of injection of 3-acetylpyridine on the levels of taurine in the cerebellum and medulla of the rat: A reappraisal

B. H. Rohde, W. J. McBride

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Values for taurine in a 5% TCA extract of whole rat medulla were decreased by 19% after acid hydrolysis of samples. Values for taurine in a similar extract of rat cerebellum were unaffected by hydrolysis. The values for taurine were lower in the medulla and cerebellum of 3-acetylpyridine treated rat (65 mg/kg i.p.) when the unhydrolyzed TCA extract was assayed. However, when the hydrolyzed TCA extract was assayed, the level of taurine in the medulla was not lower in the 3-AP treatment rat but it was reduced in the cerebella of the drug-treated group. 3-Acetylpyridine appeared to reduce the levels in the medulla of acid-labile compounds which can interfere with the estimation of taurine.

Original languageEnglish (US)
Pages (from-to)845-848
Number of pages4
JournalNeurochemical Research
Volume7
Issue number7
DOIs
StatePublished - Jul 1 1982

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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