Effects of intramuscular administration of recombinant bovine interferon-alpha I1 during the period of maternal recognition of pregnancy.

Kenneth Nephew, K. E. McClure, M. L. Day, S. Xie, R. M. Roberts, W. F. Pope

Research output: Contribution to journalArticle

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Abstract

One hundred ewes were utilized to determine the effects of interferon supplementation on the number of ewes pregnant and embryonic survival. Ewes were checked twice daily (0700 and 1600) for estrus using fertile rams. On d 12 through 16, ewes received twice-daily i.m. injections of either recombinant bovine interferon alpha I1 (2 mg IFN) or vehicle. Ewes remained penned with rams and were observed for subsequent estrous activity for at least 35 d after mating. To determine the number of fetuses and corpora lutea, all ewes were subjected to one surgery during mid-pregnancy (d 45 to 80). More (P less than .05) ewes were pregnant after treatment with IFN vs vehicle (45 of 49, 92% vs 37 of 49, 76%, respectively). The interestrous interval for ewes that were treated with IFN and did not conceive was longer (P less than .05) than for ewes given vehicle (26 +/- 1 vs 17 +/- 2 d, respectively). Embryonic survival (98.2 vs 87.9%; P less than .05), calculated as the number of fetuses present at the time of laparotomy and expressed as a percentage of the ovulation rate, and percentage of ewes with 100% fetal survival (96 vs 76%; P less than .05) were greater after treatment with IFN. It was concluded that supplementation of IFN increased both the number of ewes pregnant and embryonic survival.

Original languageEnglish (US)
Pages (from-to)2766-2770
Number of pages5
JournalJournal of Animal Science
Volume68
Issue number9
StatePublished - Sep 1990
Externally publishedYes

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interferon-alpha
intramuscular injection
Interferon-alpha
ewes
Fetus
Mothers
pregnancy
Pregnancy
cattle
Corpus Luteum
Estrus
Ovulation
Laparotomy
Interferons
Injections
Therapeutics
rams
fetus
laparotomy
interferons

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effects of intramuscular administration of recombinant bovine interferon-alpha I1 during the period of maternal recognition of pregnancy. / Nephew, Kenneth; McClure, K. E.; Day, M. L.; Xie, S.; Roberts, R. M.; Pope, W. F.

In: Journal of Animal Science, Vol. 68, No. 9, 09.1990, p. 2766-2770.

Research output: Contribution to journalArticle

Nephew, Kenneth ; McClure, K. E. ; Day, M. L. ; Xie, S. ; Roberts, R. M. ; Pope, W. F. / Effects of intramuscular administration of recombinant bovine interferon-alpha I1 during the period of maternal recognition of pregnancy. In: Journal of Animal Science. 1990 ; Vol. 68, No. 9. pp. 2766-2770.
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abstract = "One hundred ewes were utilized to determine the effects of interferon supplementation on the number of ewes pregnant and embryonic survival. Ewes were checked twice daily (0700 and 1600) for estrus using fertile rams. On d 12 through 16, ewes received twice-daily i.m. injections of either recombinant bovine interferon alpha I1 (2 mg IFN) or vehicle. Ewes remained penned with rams and were observed for subsequent estrous activity for at least 35 d after mating. To determine the number of fetuses and corpora lutea, all ewes were subjected to one surgery during mid-pregnancy (d 45 to 80). More (P less than .05) ewes were pregnant after treatment with IFN vs vehicle (45 of 49, 92{\%} vs 37 of 49, 76{\%}, respectively). The interestrous interval for ewes that were treated with IFN and did not conceive was longer (P less than .05) than for ewes given vehicle (26 +/- 1 vs 17 +/- 2 d, respectively). Embryonic survival (98.2 vs 87.9{\%}; P less than .05), calculated as the number of fetuses present at the time of laparotomy and expressed as a percentage of the ovulation rate, and percentage of ewes with 100{\%} fetal survival (96 vs 76{\%}; P less than .05) were greater after treatment with IFN. It was concluded that supplementation of IFN increased both the number of ewes pregnant and embryonic survival.",
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