Effects of isoniazid on hepatic drug oxidation and N-acetylation capacities in rats

Zeruesenay Desta, W. Siegmund, G. Franke, A. Beyrich, H. Bleyer

Research output: Contribution to journalArticle

Abstract

In vitro and in vivo activity of hepatic monooxygenase as well as in vivo N-acetylation capacity were assessed in male Wistar rats after oral pretreatment with 10 and 50 mg/kg isoniazid for 7 d. Both doses of isoniazid showed no statistical difference in protein contents, total cytochrome P-450 and the activities of aminopyrine N-demethylase as well as ethoxyresorufin-O-deethylase in the 9000 x g liver homogenate suspension compared to the saline pretreated group. Body and relative liver weights remained also unchanged. In vivo isoniazid pretreatment with either dose hardly changed the kinetic profiles and parameters of phenazone and sulfadimidine (free + total). The results suggest that drug metabolizing pathways that can be evaluated by the metabolism of the model substances employed here may not be modified by prolonged isoniazid treatment.

Original languageEnglish
Pages (from-to)448-451
Number of pages4
JournalPharmazie
Volume47
Issue number6
StatePublished - 1992
Externally publishedYes

Fingerprint

Acetylation
Isoniazid
Rats
Oxidation
Liver
Pharmaceutical Preparations
Aminopyrine N-Demethylase
Sulfamethazine
Antipyrine
Cytochrome P-450 CYP1A1
Mixed Function Oxygenases
Metabolism
Cytochrome P-450 Enzyme System
Wistar Rats
Suspensions
Weights and Measures
Kinetics
Proteins

ASJC Scopus subject areas

  • Molecular Medicine
  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Pharmacology

Cite this

Desta, Z., Siegmund, W., Franke, G., Beyrich, A., & Bleyer, H. (1992). Effects of isoniazid on hepatic drug oxidation and N-acetylation capacities in rats. Pharmazie, 47(6), 448-451.

Effects of isoniazid on hepatic drug oxidation and N-acetylation capacities in rats. / Desta, Zeruesenay; Siegmund, W.; Franke, G.; Beyrich, A.; Bleyer, H.

In: Pharmazie, Vol. 47, No. 6, 1992, p. 448-451.

Research output: Contribution to journalArticle

Desta, Z, Siegmund, W, Franke, G, Beyrich, A & Bleyer, H 1992, 'Effects of isoniazid on hepatic drug oxidation and N-acetylation capacities in rats', Pharmazie, vol. 47, no. 6, pp. 448-451.
Desta Z, Siegmund W, Franke G, Beyrich A, Bleyer H. Effects of isoniazid on hepatic drug oxidation and N-acetylation capacities in rats. Pharmazie. 1992;47(6):448-451.
Desta, Zeruesenay ; Siegmund, W. ; Franke, G. ; Beyrich, A. ; Bleyer, H. / Effects of isoniazid on hepatic drug oxidation and N-acetylation capacities in rats. In: Pharmazie. 1992 ; Vol. 47, No. 6. pp. 448-451.
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