Effects of long-term cocaine exposure on spermatogenesis and fertility in peripubertal male rats

Valal K. George, Haikun Li, Claudio Teloken, David Grignon, W. Dwayne Lawrence, C. B. Dhabuwala

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Purpose: This study was conducted to investigate the effects of long-term administration of cocaine on spermatogenesis and fertility in adult male rats. Materials and Methods: Thirty-day-old male Sprague-Dawley rats were given cocaine hydrochloride (15 mg./kg. body weight, corresponding to an average single dose for a heavy cocaine user) either daily or twice weekly (weekend group, cocaine given on Saturday and Sunday) and mated with pregnancy-proven female rats after 100 and 150 days of exposure to the drug. Pregnancy rates and litter birth weights were evaluated. Serum testosterone, follicle stimulating hormone and luteinizing hormone levels were measured in all adult rats. Morphologic analysis of the testis entailed the evaluation of quantitative and qualitative histologic parameters to assess the effect of cocaine on various stages of spermatogenesis. Results: After 100 days of treatment, the rats receiving daily cocaine had a pregnancy rate of only 33% versus 86% for the controls (p

Original languageEnglish (US)
Pages (from-to)327-331
Number of pages5
JournalJournal of Urology
Volume155
Issue number1
StatePublished - Jan 1996
Externally publishedYes

Fingerprint

Spermatogenesis
Cocaine
Fertility
Pregnancy Rate
Follicle Stimulating Hormone
Luteinizing Hormone
Birth Weight
Sprague Dawley Rats
Testosterone
Testis
Body Weight
Pregnancy
Serum
Pharmaceutical Preparations

Keywords

  • Cocaine
  • Fertility
  • Spermatids
  • Spermatogenesis
  • Testis

ASJC Scopus subject areas

  • Urology

Cite this

George, V. K., Li, H., Teloken, C., Grignon, D., Lawrence, W. D., & Dhabuwala, C. B. (1996). Effects of long-term cocaine exposure on spermatogenesis and fertility in peripubertal male rats. Journal of Urology, 155(1), 327-331.

Effects of long-term cocaine exposure on spermatogenesis and fertility in peripubertal male rats. / George, Valal K.; Li, Haikun; Teloken, Claudio; Grignon, David; Lawrence, W. Dwayne; Dhabuwala, C. B.

In: Journal of Urology, Vol. 155, No. 1, 01.1996, p. 327-331.

Research output: Contribution to journalArticle

George, VK, Li, H, Teloken, C, Grignon, D, Lawrence, WD & Dhabuwala, CB 1996, 'Effects of long-term cocaine exposure on spermatogenesis and fertility in peripubertal male rats', Journal of Urology, vol. 155, no. 1, pp. 327-331.
George, Valal K. ; Li, Haikun ; Teloken, Claudio ; Grignon, David ; Lawrence, W. Dwayne ; Dhabuwala, C. B. / Effects of long-term cocaine exposure on spermatogenesis and fertility in peripubertal male rats. In: Journal of Urology. 1996 ; Vol. 155, No. 1. pp. 327-331.
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