Effects of long-term exercise on arrhythmogenesis in aged hypertensive rats

Yen Ling Sung, Chih En Wu, Jhen Yang Syu, Terry B.J. Kuo, Jai Yi Li, Chieh Wen Chen, Ching Hui Weng, Wei Hsuan Hsu, Shih Ann Chen, Yu Feng Hu, Shien-Fong Lin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Chronic hypertension is a multifactorial disease that is highly associated with cardiovascular disorders. Physical activity, such as long-term exercise, is advocated as a treatment for hypertension, but the responses of different age groups to long-term exercise are unknown. We used aged spontaneous hypertensive rats (SHRs, 80 weeks old) to test the hypothesis that long-term exercise compensated for deficient autonomic control and reduced susceptibility to ventricular tachycardia (VT) and ventricular fibrillation (VF) in this animal model. The aged SHRs were divided into control and voluntary exercise groups. Ambulatory electrocardiography was recorded for the heart rate variability (HRV) analysis. Programmed stimulation was applied to exposed hearts to induce ventricular arrhythmia in situ. Then, the hearts were isolated for an optical mapping study. The results showed that increased HRV indices were broadly related to vagal dominance in the high-intensity exercise group. Exercise altered the electrical propagation dynamic properties, such as the action potential duration restitution (APDR). Furthermore, the VF inducibility decreased with increased exercise intensity. Taken together, our results suggest that long-term exercise reduces the risk of arrhythmogenesis in aged SHRs through enhanced vagal control and stabilized electrical dynamics.

Original languageEnglish (US)
JournalComputers in Biology and Medicine
DOIs
StateAccepted/In press - Jan 1 2018
Externally publishedYes

Fingerprint

Rats
Exercise
Electrocardiography
Ventricular Fibrillation
Animals
Heart Rate
Hypertension
Ambulatory Electrocardiography
Inbred SHR Rats
Ventricular Tachycardia
Action Potentials
Cardiac Arrhythmias
Animal Models
Age Groups

Keywords

  • Exercise
  • Heart rate variability
  • Spontaneously hypertensive rat
  • Ventricular tachycardia

ASJC Scopus subject areas

  • Computer Science Applications
  • Health Informatics

Cite this

Effects of long-term exercise on arrhythmogenesis in aged hypertensive rats. / Sung, Yen Ling; Wu, Chih En; Syu, Jhen Yang; Kuo, Terry B.J.; Li, Jai Yi; Chen, Chieh Wen; Weng, Ching Hui; Hsu, Wei Hsuan; Chen, Shih Ann; Hu, Yu Feng; Lin, Shien-Fong.

In: Computers in Biology and Medicine, 01.01.2018.

Research output: Contribution to journalArticle

Sung, Yen Ling ; Wu, Chih En ; Syu, Jhen Yang ; Kuo, Terry B.J. ; Li, Jai Yi ; Chen, Chieh Wen ; Weng, Ching Hui ; Hsu, Wei Hsuan ; Chen, Shih Ann ; Hu, Yu Feng ; Lin, Shien-Fong. / Effects of long-term exercise on arrhythmogenesis in aged hypertensive rats. In: Computers in Biology and Medicine. 2018.
@article{a12e35f2074b4267b455ae8cc74e2aac,
title = "Effects of long-term exercise on arrhythmogenesis in aged hypertensive rats",
abstract = "Chronic hypertension is a multifactorial disease that is highly associated with cardiovascular disorders. Physical activity, such as long-term exercise, is advocated as a treatment for hypertension, but the responses of different age groups to long-term exercise are unknown. We used aged spontaneous hypertensive rats (SHRs, 80 weeks old) to test the hypothesis that long-term exercise compensated for deficient autonomic control and reduced susceptibility to ventricular tachycardia (VT) and ventricular fibrillation (VF) in this animal model. The aged SHRs were divided into control and voluntary exercise groups. Ambulatory electrocardiography was recorded for the heart rate variability (HRV) analysis. Programmed stimulation was applied to exposed hearts to induce ventricular arrhythmia in situ. Then, the hearts were isolated for an optical mapping study. The results showed that increased HRV indices were broadly related to vagal dominance in the high-intensity exercise group. Exercise altered the electrical propagation dynamic properties, such as the action potential duration restitution (APDR). Furthermore, the VF inducibility decreased with increased exercise intensity. Taken together, our results suggest that long-term exercise reduces the risk of arrhythmogenesis in aged SHRs through enhanced vagal control and stabilized electrical dynamics.",
keywords = "Exercise, Heart rate variability, Spontaneously hypertensive rat, Ventricular tachycardia",
author = "Sung, {Yen Ling} and Wu, {Chih En} and Syu, {Jhen Yang} and Kuo, {Terry B.J.} and Li, {Jai Yi} and Chen, {Chieh Wen} and Weng, {Ching Hui} and Hsu, {Wei Hsuan} and Chen, {Shih Ann} and Hu, {Yu Feng} and Shien-Fong Lin",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.compbiomed.2018.08.016",
language = "English (US)",
journal = "Computers in Biology and Medicine",
issn = "0010-4825",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Effects of long-term exercise on arrhythmogenesis in aged hypertensive rats

AU - Sung, Yen Ling

AU - Wu, Chih En

AU - Syu, Jhen Yang

AU - Kuo, Terry B.J.

AU - Li, Jai Yi

AU - Chen, Chieh Wen

AU - Weng, Ching Hui

AU - Hsu, Wei Hsuan

AU - Chen, Shih Ann

AU - Hu, Yu Feng

AU - Lin, Shien-Fong

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Chronic hypertension is a multifactorial disease that is highly associated with cardiovascular disorders. Physical activity, such as long-term exercise, is advocated as a treatment for hypertension, but the responses of different age groups to long-term exercise are unknown. We used aged spontaneous hypertensive rats (SHRs, 80 weeks old) to test the hypothesis that long-term exercise compensated for deficient autonomic control and reduced susceptibility to ventricular tachycardia (VT) and ventricular fibrillation (VF) in this animal model. The aged SHRs were divided into control and voluntary exercise groups. Ambulatory electrocardiography was recorded for the heart rate variability (HRV) analysis. Programmed stimulation was applied to exposed hearts to induce ventricular arrhythmia in situ. Then, the hearts were isolated for an optical mapping study. The results showed that increased HRV indices were broadly related to vagal dominance in the high-intensity exercise group. Exercise altered the electrical propagation dynamic properties, such as the action potential duration restitution (APDR). Furthermore, the VF inducibility decreased with increased exercise intensity. Taken together, our results suggest that long-term exercise reduces the risk of arrhythmogenesis in aged SHRs through enhanced vagal control and stabilized electrical dynamics.

AB - Chronic hypertension is a multifactorial disease that is highly associated with cardiovascular disorders. Physical activity, such as long-term exercise, is advocated as a treatment for hypertension, but the responses of different age groups to long-term exercise are unknown. We used aged spontaneous hypertensive rats (SHRs, 80 weeks old) to test the hypothesis that long-term exercise compensated for deficient autonomic control and reduced susceptibility to ventricular tachycardia (VT) and ventricular fibrillation (VF) in this animal model. The aged SHRs were divided into control and voluntary exercise groups. Ambulatory electrocardiography was recorded for the heart rate variability (HRV) analysis. Programmed stimulation was applied to exposed hearts to induce ventricular arrhythmia in situ. Then, the hearts were isolated for an optical mapping study. The results showed that increased HRV indices were broadly related to vagal dominance in the high-intensity exercise group. Exercise altered the electrical propagation dynamic properties, such as the action potential duration restitution (APDR). Furthermore, the VF inducibility decreased with increased exercise intensity. Taken together, our results suggest that long-term exercise reduces the risk of arrhythmogenesis in aged SHRs through enhanced vagal control and stabilized electrical dynamics.

KW - Exercise

KW - Heart rate variability

KW - Spontaneously hypertensive rat

KW - Ventricular tachycardia

UR - http://www.scopus.com/inward/record.url?scp=85052135701&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052135701&partnerID=8YFLogxK

U2 - 10.1016/j.compbiomed.2018.08.016

DO - 10.1016/j.compbiomed.2018.08.016

M3 - Article

JO - Computers in Biology and Medicine

JF - Computers in Biology and Medicine

SN - 0010-4825

ER -