Effects of low-level light therapy on hepatic antioxidant defense in acute and chronic diabetic rats

Jinhwan Lim, Zeeshan M. Ali, Ruth A. Sanders, Ann C. Snyder, Janis T. Eells, Diane S. Henshel, John B. Watkins

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Diabetes causes oxidative stress in the liver and other tissues prone to complications. Photobiomodulation by near infrared light (670 nm) has been shown to accelerate diabetic wound healing, improve recovery from oxidative injury in the kidney, and attenuate degeneration in retina and optic nerve. The present study tested the hypothesis that 670 nm photobiomodulation, a low-level light therapy, would attenuate oxidative stress and enhance the antioxidant protection system in the liver of a model of type I diabetes. Male Wistar rats were made diabetic with strep- tozotocin (50 mg/kg, ip) then exposed to 670 nm light (9 J/cm2) once per day for 18 days (acute) or 14 weeks (chronic). Livers were harvested, flash frozen, and then assayed for markers of oxidative stress. Light treatment was ineffective as an antioxidant therapy in chronic diabetes, but light treatment for 18 days in acutely diabetic rats resulted in the normalization of hepatic glutathione reductase and superoxide dismutase activities and a significant increase in glutathione per-oxidase and glutathione-S transferase activities. The results of this study suggest that 670 nm photobiomodulation may reduce, at least in part, acute hepatic oxidative stress by enhancing the antioxidant defense system in the diabetic rat model.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalJournal of Biochemical and Molecular Toxicology
Issue number1
StatePublished - Jan 1 2009


  • Antioxidant enzymes
  • Hyperglycemia
  • Liver
  • Oxidative stress
  • Photo-biomodulation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Molecular Medicine
  • Toxicology
  • Health, Toxicology and Mutagenesis

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