Effects of low-level light therapy on streptozotocin-induced diabetic kidney

Jinhwan Lim, Ruth A. Sanders, Ann C. Snyder, Janis T. Eells, Diane S. Henshel, John B. Watkins

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Hyperglycemia causes oxidative damage in tissues prone to complications in diabetes. Low-level light therapy (LLLT) in the red to near infrared range (630-1000nm) has been shown to accelerate diabetic wound healing. To test the hypothesis that LLLT would attenuate oxidative renal damage in Type I diabetic rats, male Wistar rats were made diabetic with streptozotocin (50mg/kg, ip), and then exposed to 670nm light at a dose of 9J/cm2 once per day for 14weeks. The activity and expression of catalase and the activity of Na K-ATPase increased in kidneys of light-treated diabetic rats, whereas the activity and expression of glutathione peroxidase and the expression of Na K-ATPase were unchanged. LLLT lowered the values of serum BUN, serum creatinine, and BUN/creatinine ratio. In addition, LLLT augmented the activity and expression of cytochrome c oxidase, a primary photoacceptor molecule in the mitochondrial respiratory chain, and reduced the formation of the DNA adduct 8-hydroxy-2′-deoxyguanosine in kidney. LLLT improved renal function and antioxidant defense capabilities in the kidney of Type I diabetic rats. Thus, 670nm LLLT may be broadly applicable to the amelioration of renal complications induced by diabetes that disrupt antioxidant defense mechanisms.

Original languageEnglish (US)
Pages (from-to)105-110
Number of pages6
JournalJournal of Photochemistry and Photobiology B: Biology
Volume99
Issue number2
DOIs
StatePublished - May 1 2010

Keywords

  • Antioxidant defense
  • Diabetes
  • Kidney
  • Low-level light therapy

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Biophysics

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