Effects of low-level light therapy on streptozotocin-induced diabetic kidney

Jinhwan Lim, Ruth A. Sanders, Ann C. Snyder, Janis T. Eells, Diane S. Henshel, John B. Watkins

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Hyperglycemia causes oxidative damage in tissues prone to complications in diabetes. Low-level light therapy (LLLT) in the red to near infrared range (630-1000nm) has been shown to accelerate diabetic wound healing. To test the hypothesis that LLLT would attenuate oxidative renal damage in Type I diabetic rats, male Wistar rats were made diabetic with streptozotocin (50mg/kg, ip), and then exposed to 670nm light at a dose of 9J/cm2 once per day for 14weeks. The activity and expression of catalase and the activity of Na K-ATPase increased in kidneys of light-treated diabetic rats, whereas the activity and expression of glutathione peroxidase and the expression of Na K-ATPase were unchanged. LLLT lowered the values of serum BUN, serum creatinine, and BUN/creatinine ratio. In addition, LLLT augmented the activity and expression of cytochrome c oxidase, a primary photoacceptor molecule in the mitochondrial respiratory chain, and reduced the formation of the DNA adduct 8-hydroxy-2′-deoxyguanosine in kidney. LLLT improved renal function and antioxidant defense capabilities in the kidney of Type I diabetic rats. Thus, 670nm LLLT may be broadly applicable to the amelioration of renal complications induced by diabetes that disrupt antioxidant defense mechanisms.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalJournal of Photochemistry and Photobiology B: Biology
Volume99
Issue number2
DOIs
StatePublished - May 2010

Fingerprint

kidneys
Streptozocin
therapy
Kidney
rats
Blood Urea Nitrogen
creatinine
Diabetes Complications
Creatinine
antioxidants
Antioxidants
serums
Light
hyperglycemia
DNA Adducts
renal function
Electron Transport Complex IV
Glutathione Peroxidase
Electron Transport
damage

Keywords

  • Antioxidant defense
  • Diabetes
  • Kidney
  • Low-level light therapy

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Biophysics

Cite this

Effects of low-level light therapy on streptozotocin-induced diabetic kidney. / Lim, Jinhwan; Sanders, Ruth A.; Snyder, Ann C.; Eells, Janis T.; Henshel, Diane S.; Watkins, John B.

In: Journal of Photochemistry and Photobiology B: Biology, Vol. 99, No. 2, 05.2010, p. 105-110.

Research output: Contribution to journalArticle

Lim, Jinhwan ; Sanders, Ruth A. ; Snyder, Ann C. ; Eells, Janis T. ; Henshel, Diane S. ; Watkins, John B. / Effects of low-level light therapy on streptozotocin-induced diabetic kidney. In: Journal of Photochemistry and Photobiology B: Biology. 2010 ; Vol. 99, No. 2. pp. 105-110.
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