Objective: To investigate the effect of nicotine on monoamine mediated behaviour in laboratory animals. Methods: The effect of intraperitoneal administration of nicotine was studied on the monoamine mediated behaviour in rats or mice. The effect of nicotine on dopamine mediated behaviour was studied by observing the effect on amphetamine-induced stereotyped behaviour, sensitivity of alcohol withdrawn mice to pentylenetetrazol, and haloperidol-induced catalepsy. The effect on serotonin mediated behaviour was studied by observing the effect on lithium induced head twitches in rats and the effect on noradrenaline mediated behaviour was studied by observing the effect on clonidine induced hypothermia in rats. The effect on behavioural despair induced by forced swimming was also studied to explore its antidepressant potential. Results: Nicotine potentiated amphetamine-induced stereotyped behaviour, both after acute and chronic administration. It delayed haloperidol-induced catalepsy and aggravated symptoms of alcohol withdrawal. It decreased lithium-induced head twitches and diminished the noradrenaline mediated behaviour. Nicotine potentiated the antidepressant activity of amitriptyline. Conclusion: Nicotine modified the behavioural effects mediated via monoamine neurotransmitters and potentiated antidepressant activity of amitriptyline.
|Original language||English (US)|
|Number of pages||6|
|Journal||Indian Journal of Pharmacology|
|State||Published - Dec 1 1999|
ASJC Scopus subject areas
- Pharmacology (medical)