Effects of nonsteroidal anti-inflammatory drugs on bone formation and soft-tissue healing.

Laurence E. Dahners, Brian H. Mullis

Research output: Contribution to journalReview article

121 Scopus citations


Nonsteroidal anti-inflammatory drugs continue to be prescribed as analgesics for patients with healing fractures even though these drugs diminish bone formation, healing, and remodeling. Inhibition of bone formation can be clinically useful in preventing heterotopic ossification in selected clinical situations. In this regard, naproxen may be more efficacious than the traditional indomethacin, and short-term administration is as effective as long-term. When fracture healing or spine fusion is desired, nonsteroidal anti-inflammatory drugs should be avoided. Some nonsteroidal anti-inflammatory drugs have a positive effect on soft-tissue healing; they stimulate collagen synthesis and can increase strength in the early phases of repair during skin and ligament healing. Cyclooxygenase-2 inhibitors have an adverse effect on bone healing and may have an adverse effect on ligament healing. Therefore, further investigation is necessary to confirm that traditional nonsteroidal anti-inflammatory drugs may be preferable for the healing of collagenous tissues.

Original languageEnglish (US)
Pages (from-to)139-143
Number of pages5
JournalThe Journal of the American Academy of Orthopaedic Surgeons
Issue number3
StatePublished - Jan 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Fingerprint Dive into the research topics of 'Effects of nonsteroidal anti-inflammatory drugs on bone formation and soft-tissue healing.'. Together they form a unique fingerprint.

  • Cite this