Effects of occlusion on the skin of atopic dermatitis patients

Kristen Kobaly, Ally-Khan Somani, Thomas McCormick, Susan T. Nedorost

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Atopic dermatitis (AD) may be exacerbated by occlusion from items such as occlusive gloves or textiles, especially if the occlusion is removed suddenly, creating a steep humidity gradient. Most previous studies of occlusion have focused on normal skin. Occlusion has been shown to be beneficial in psoriatic skin, but many atopic patients complain of increased inflammation after occlusion. Objective: To evaluate the response of noninflamed AD skin to occlusion. Methods: Six patients with AD were patch-tested with occlusive polyethylene wrap and sodium lauryl sulfate (SLS) in standard Finn Chambers taped to noninflamed skin of the back. Cytokine and chemokine messenger ribonucleic acid (mRNA) for interleukin-8 (IL-8), interleukin-1 alpha (IL-1α), and interleukin-1 receptor antagonist (IL-1RA), as well as the 18S rRNA housekeeping gene, was obtained via tape-stripping the skin and measured using quantitative real-time polymerase chain reaction. We also measured transepidermal water loss after removal of occlusion. Results: Polyethylene occlusion alone with abrupt removal induced IL-8 and IL-1α levels similar to or exceeding that of SLS. IL-1RA was up-regulated by SLS and occlusion, with SLS showing a stronger response. Conclusion: Removal of occlusion with polyethylene film up-regulates the inflammatory cytokines IL-8, IL-1α, and IL-1RA in patients with AD. This may explain the worsening of AD with the use of occlusive gloves, athletic equipment, and fabrics.

Original languageEnglish (US)
Pages (from-to)255-261
Number of pages7
JournalDermatitis
Volume21
Issue number5
DOIs
StatePublished - Oct 1 2010
Externally publishedYes

Fingerprint

Atopic Dermatitis
Sodium Dodecyl Sulfate
Interleukin-1alpha
Interleukin-1 Receptors
Polyethylene
Skin
Interleukin-8
Sports Equipment
Surgical Tape
Cytokines
Textiles
Essential Genes
Humidity
rRNA Genes
Chemokines
Real-Time Polymerase Chain Reaction
Up-Regulation
RNA
Inflammation
Water

ASJC Scopus subject areas

  • Dermatology
  • Immunology and Allergy

Cite this

Effects of occlusion on the skin of atopic dermatitis patients. / Kobaly, Kristen; Somani, Ally-Khan; McCormick, Thomas; Nedorost, Susan T.

In: Dermatitis, Vol. 21, No. 5, 01.10.2010, p. 255-261.

Research output: Contribution to journalArticle

Kobaly, Kristen ; Somani, Ally-Khan ; McCormick, Thomas ; Nedorost, Susan T. / Effects of occlusion on the skin of atopic dermatitis patients. In: Dermatitis. 2010 ; Vol. 21, No. 5. pp. 255-261.
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