Effects of parity on pregnancy hormonal profiles across ethnic groups with a diverse incidence of breast cancer

Alan A. Arslan, Anne Zeleniuch-Jacquotte, Annekatrin Lukanova, Yelena Afanasyeva, Joseph Katz, Mortimer Levitz, Giuseppe Del Priore, Paolo Toniolo

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Epidemiologic evidence suggests that a full-term pregnancy may affect maternal risk of breast cancer later in life. The objective of this cross-sectional study was to compare circulating levels of maternal hormones affecting breast differentiation (human chorionic gonadotropin and prolactin) and proliferation [α-fetoprotein, insulin-like growth factor I (IGF-I), and estradiol] between women at a low to moderate risk (Asians and Hispanics), as compared with women at a high risk for breast cancer (Caucasians and African-Americans). Between May 2002 and December 2004, a total of 586 pregnant women were approached during a routine prenatal visit. Among them, 450 women (206 Caucasian, 126 Asian, 88 Hispanic, and 30 African-American) met the inclusion criteria and signed the informed consent. Only singleton pregnancies were considered. Blood samples were drawn during the second trimester of pregnancy. Laboratory analyses were done using the IMMULITE 2000 immunoassay system. Gestational age standardized mean levels of estradiol, IGF-I, and prolactin were significantly higher in Hispanic women compared with Caucasian women. Mean concentration of IGF-I was significantly higher in African-American women compared with Caucasian and Asian women. No significant differences in pregnancy hormone levels were observed between Caucasian and Asian (predominantly second-generation Chinese) women in this study. Irrespective of ethnicity, women who had their first pregnancy had substantially higher mean levels of α-fetoprotein, human chorionic gonadotropin, estradiol, and prolactin compared with women who previously had at least one full-term pregnancy. These data suggest that circulating pregnancy hormone levels may explain some of the ethnic differences in breast cancer risk.

Original languageEnglish (US)
Pages (from-to)2123-2130
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume15
Issue number11
DOIs
StatePublished - Nov 1 2006

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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    Arslan, A. A., Zeleniuch-Jacquotte, A., Lukanova, A., Afanasyeva, Y., Katz, J., Levitz, M., Del Priore, G., & Toniolo, P. (2006). Effects of parity on pregnancy hormonal profiles across ethnic groups with a diverse incidence of breast cancer. Cancer Epidemiology Biomarkers and Prevention, 15(11), 2123-2130. https://doi.org/10.1158/1055-9965.EPI-06-0470