Effects of phospholipids on renal function

V. M. Buckalew, J. W. Strandhoy, Rajash Handa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effects of two classes of phospholipids (PL) on renal function have been studied. Bolus injections of 1 ng (10 pmol) of lysophosphatidylcholine (LPC) caused natriuresis and diuresis in rats. Natriuretic activity was eliminated by substituting unsaturated bonds in the 1-acyl group and by removing the choline group on the sn-3 position. Natriuretic activity was not affected by substitution of 1-alkyl for 1-acyl groups. In the dog, LPC was natriuretic when given as a bolus of 3.0 μg/kg or as a constant infusion at 5 ng/kg/min. To explore further the effect of alkyl PLs on renal function, a series of studies with platelet activating factor (PAF) was performed. PAF injected directly into the renal artery (IR) in bolus doses of 0.5-10 ng/kg caused renal vasodilation that was blocked by a specific PAF receptor antagonist. This effect was not due to release of vasodilatory eicosanoids, dopamine, or nitric oxide (NO). PAF given IR as a continuous infusion at 2.5 ng/kg/min attenuated the renal vasoconstrictor effects of angiotensin II and norepinephrine but not vasopressin. This effect to attenuate vasoconstriction was blocked by the NO inhibitor N-monomethyl-L-arginine. These studies using picomolar amounts of PL suggest a physiologic role for these compounds in control of renal function.

Original languageEnglish (US)
JournalJournal of Cardiovascular Pharmacology
Volume22
Issue numberSUPPL. 2
StatePublished - 1993
Externally publishedYes

Fingerprint

Phospholipids
Platelet Activating Factor
Kidney
Lysophosphatidylcholines
Renal Artery
Nitric Oxide
Natriuresis
Eicosanoids
Diuresis
Vasoconstrictor Agents
Choline
Vasoconstriction
Vasopressins
Vasodilation
Angiotensin II
Arginine
Dopamine
Norepinephrine
Dogs
Injections

Keywords

  • Phospholipids
  • Platelet activating factor
  • Renal function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

Effects of phospholipids on renal function. / Buckalew, V. M.; Strandhoy, J. W.; Handa, Rajash.

In: Journal of Cardiovascular Pharmacology, Vol. 22, No. SUPPL. 2, 1993.

Research output: Contribution to journalArticle

Buckalew, VM, Strandhoy, JW & Handa, R 1993, 'Effects of phospholipids on renal function', Journal of Cardiovascular Pharmacology, vol. 22, no. SUPPL. 2.
Buckalew, V. M. ; Strandhoy, J. W. ; Handa, Rajash. / Effects of phospholipids on renal function. In: Journal of Cardiovascular Pharmacology. 1993 ; Vol. 22, No. SUPPL. 2.
@article{892fe381dcaf47b09171ef850eaea193,
title = "Effects of phospholipids on renal function",
abstract = "The effects of two classes of phospholipids (PL) on renal function have been studied. Bolus injections of 1 ng (10 pmol) of lysophosphatidylcholine (LPC) caused natriuresis and diuresis in rats. Natriuretic activity was eliminated by substituting unsaturated bonds in the 1-acyl group and by removing the choline group on the sn-3 position. Natriuretic activity was not affected by substitution of 1-alkyl for 1-acyl groups. In the dog, LPC was natriuretic when given as a bolus of 3.0 μg/kg or as a constant infusion at 5 ng/kg/min. To explore further the effect of alkyl PLs on renal function, a series of studies with platelet activating factor (PAF) was performed. PAF injected directly into the renal artery (IR) in bolus doses of 0.5-10 ng/kg caused renal vasodilation that was blocked by a specific PAF receptor antagonist. This effect was not due to release of vasodilatory eicosanoids, dopamine, or nitric oxide (NO). PAF given IR as a continuous infusion at 2.5 ng/kg/min attenuated the renal vasoconstrictor effects of angiotensin II and norepinephrine but not vasopressin. This effect to attenuate vasoconstriction was blocked by the NO inhibitor N-monomethyl-L-arginine. These studies using picomolar amounts of PL suggest a physiologic role for these compounds in control of renal function.",
keywords = "Phospholipids, Platelet activating factor, Renal function",
author = "Buckalew, {V. M.} and Strandhoy, {J. W.} and Rajash Handa",
year = "1993",
language = "English (US)",
volume = "22",
journal = "Journal of Cardiovascular Pharmacology",
issn = "0160-2446",
publisher = "Lippincott Williams and Wilkins",
number = "SUPPL. 2",

}

TY - JOUR

T1 - Effects of phospholipids on renal function

AU - Buckalew, V. M.

AU - Strandhoy, J. W.

AU - Handa, Rajash

PY - 1993

Y1 - 1993

N2 - The effects of two classes of phospholipids (PL) on renal function have been studied. Bolus injections of 1 ng (10 pmol) of lysophosphatidylcholine (LPC) caused natriuresis and diuresis in rats. Natriuretic activity was eliminated by substituting unsaturated bonds in the 1-acyl group and by removing the choline group on the sn-3 position. Natriuretic activity was not affected by substitution of 1-alkyl for 1-acyl groups. In the dog, LPC was natriuretic when given as a bolus of 3.0 μg/kg or as a constant infusion at 5 ng/kg/min. To explore further the effect of alkyl PLs on renal function, a series of studies with platelet activating factor (PAF) was performed. PAF injected directly into the renal artery (IR) in bolus doses of 0.5-10 ng/kg caused renal vasodilation that was blocked by a specific PAF receptor antagonist. This effect was not due to release of vasodilatory eicosanoids, dopamine, or nitric oxide (NO). PAF given IR as a continuous infusion at 2.5 ng/kg/min attenuated the renal vasoconstrictor effects of angiotensin II and norepinephrine but not vasopressin. This effect to attenuate vasoconstriction was blocked by the NO inhibitor N-monomethyl-L-arginine. These studies using picomolar amounts of PL suggest a physiologic role for these compounds in control of renal function.

AB - The effects of two classes of phospholipids (PL) on renal function have been studied. Bolus injections of 1 ng (10 pmol) of lysophosphatidylcholine (LPC) caused natriuresis and diuresis in rats. Natriuretic activity was eliminated by substituting unsaturated bonds in the 1-acyl group and by removing the choline group on the sn-3 position. Natriuretic activity was not affected by substitution of 1-alkyl for 1-acyl groups. In the dog, LPC was natriuretic when given as a bolus of 3.0 μg/kg or as a constant infusion at 5 ng/kg/min. To explore further the effect of alkyl PLs on renal function, a series of studies with platelet activating factor (PAF) was performed. PAF injected directly into the renal artery (IR) in bolus doses of 0.5-10 ng/kg caused renal vasodilation that was blocked by a specific PAF receptor antagonist. This effect was not due to release of vasodilatory eicosanoids, dopamine, or nitric oxide (NO). PAF given IR as a continuous infusion at 2.5 ng/kg/min attenuated the renal vasoconstrictor effects of angiotensin II and norepinephrine but not vasopressin. This effect to attenuate vasoconstriction was blocked by the NO inhibitor N-monomethyl-L-arginine. These studies using picomolar amounts of PL suggest a physiologic role for these compounds in control of renal function.

KW - Phospholipids

KW - Platelet activating factor

KW - Renal function

UR - http://www.scopus.com/inward/record.url?scp=0027360093&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027360093&partnerID=8YFLogxK

M3 - Article

C2 - 7508037

AN - SCOPUS:0027360093

VL - 22

JO - Journal of Cardiovascular Pharmacology

JF - Journal of Cardiovascular Pharmacology

SN - 0160-2446

IS - SUPPL. 2

ER -