Effects of phospholipids on renal function

V. M. Buckalew, J. W. Strandhoy, R. K. Handa

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The effects of two classes of phospholipids (PL) on renal function have been studied. Bolus injections of 1 ng (10 pmol) of lysophosphatidylcholine (LPC) caused natriuresis and diuresis in rats. Natriuretic activity was eliminated by substituting unsaturated bonds in the 1-acyl group and by removing the choline group on the sn-3 position. Natriuretic activity was not affected by substitution of 1-alkyl for 1-acyl groups. In the dog, LPC was natriuretic when given as a bolus of 3.0 μg/kg or as a constant infusion at 5 ng/kg/min. To explore further the effect of alkyl PLs on renal function, a series of studies with platelet activating factor (PAF) was performed. PAF injected directly into the renal artery (IR) in bolus doses of 0.5-10 ng/kg caused renal vasodilation that was blocked by a specific PAF receptor antagonist. This effect was not due to release of vasodilatory eicosanoids, dopamine, or nitric oxide (NO). PAF given IR as a continuous infusion at 2.5 ng/kg/min attenuated the renal vasoconstrictor effects of angiotensin II and norepinephrine but not vasopressin. This effect to attenuate vasoconstriction was blocked by the NO inhibitor N-monomethyl-L-arginine. These studies using picomolar amounts of PL suggest a physiologic role for these compounds in control of renal function.

Original languageEnglish (US)
Pages (from-to)S79-S81
JournalJournal of cardiovascular pharmacology
Volume22
Issue numberSUPPL. 2
StatePublished - Jan 1 1993
Externally publishedYes

Keywords

  • Phospholipids
  • Platelet activating factor
  • Renal function

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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