Effects of post-natal serotonin levels on craniofacial complex

K. E. Byrd, T. A. Sheskin

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Although the role of serotonin (5-hydroxytryptamine or 5-HT) in pre-natal craniofacial growth and development has been studied, no research has been done on the effects of serotonin on post-natal craniofacial growth and development. The following experimental question was tested: What effect does increasing in vivo serotonin levels adjacent to trigeminal motoneurons have on post-natal craniofacial structures in young, actively growing rats? Forty male Sprague-Dawley rats were divided into 4 experimental groups (10% serotonin microspheres, 15% serotonin microspheres, blank microspheres, sham surgeries) and underwent stereotactic neuro-surgery at post-natal day 35; 5 rats of each group were killed at 14 and 21 post-surgical days for data collection. Statistical analyses by mixed-model, 4 × 2 repeated-measures ANOVA, and post hoc Fisher LSD tests revealed significant (P ≤ 0.05, 0.01) differences between groups and sides for muscle weight, cranial dimension, and TMJ dimension data. Data described here indicate that significant alterations of post-natal craniofacial structures can be caused by altered in vivo levels of serotonin adjacent to trigeminal motoneurons.

Original languageEnglish (US)
Pages (from-to)1730-1735
Number of pages6
JournalJournal of dental research
Issue number8
StatePublished - Jan 1 2001


  • Bone
  • Motoneuron
  • Neuromuscular
  • TMJ
  • Trigeminal

ASJC Scopus subject areas

  • Dentistry(all)

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