Effects of post-natal serotonin levels on craniofacial complex

K. E. Byrd, T. A. Sheskin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Although the role of serotonin (5-hydroxytryptamine or 5-HT) in pre-natal craniofacial growth and development has been studied, no research has been done on the effects of serotonin on post-natal craniofacial growth and development. The following experimental question was tested: What effect does increasing in vivo serotonin levels adjacent to trigeminal motoneurons have on post-natal craniofacial structures in young, actively growing rats? Forty male Sprague-Dawley rats were divided into 4 experimental groups (10% serotonin microspheres, 15% serotonin microspheres, blank microspheres, sham surgeries) and underwent stereotactic neuro-surgery at post-natal day 35; 5 rats of each group were killed at 14 and 21 post-surgical days for data collection. Statistical analyses by mixed-model, 4 × 2 repeated-measures ANOVA, and post hoc Fisher LSD tests revealed significant (P ≤ 0.05, 0.01) differences between groups and sides for muscle weight, cranial dimension, and TMJ dimension data. Data described here indicate that significant alterations of post-natal craniofacial structures can be caused by altered in vivo levels of serotonin adjacent to trigeminal motoneurons.

Original languageEnglish (US)
Pages (from-to)1730-1735
Number of pages6
JournalJournal of dental research
Volume80
Issue number8
DOIs
StatePublished - Jan 1 2001

Fingerprint

Serotonin
Microspheres
Motor Neurons
Growth and Development
Lysergic Acid Diethylamide
Temporomandibular Joint
Sprague Dawley Rats
Analysis of Variance
Weights and Measures
Muscles
Research

Keywords

  • Bone
  • Motoneuron
  • Neuromuscular
  • TMJ
  • Trigeminal

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Effects of post-natal serotonin levels on craniofacial complex. / Byrd, K. E.; Sheskin, T. A.

In: Journal of dental research, Vol. 80, No. 8, 01.01.2001, p. 1730-1735.

Research output: Contribution to journalArticle

@article{d231ee99c828468baef5db75bfb43934,
title = "Effects of post-natal serotonin levels on craniofacial complex",
abstract = "Although the role of serotonin (5-hydroxytryptamine or 5-HT) in pre-natal craniofacial growth and development has been studied, no research has been done on the effects of serotonin on post-natal craniofacial growth and development. The following experimental question was tested: What effect does increasing in vivo serotonin levels adjacent to trigeminal motoneurons have on post-natal craniofacial structures in young, actively growing rats? Forty male Sprague-Dawley rats were divided into 4 experimental groups (10{\%} serotonin microspheres, 15{\%} serotonin microspheres, blank microspheres, sham surgeries) and underwent stereotactic neuro-surgery at post-natal day 35; 5 rats of each group were killed at 14 and 21 post-surgical days for data collection. Statistical analyses by mixed-model, 4 × 2 repeated-measures ANOVA, and post hoc Fisher LSD tests revealed significant (P ≤ 0.05, 0.01) differences between groups and sides for muscle weight, cranial dimension, and TMJ dimension data. Data described here indicate that significant alterations of post-natal craniofacial structures can be caused by altered in vivo levels of serotonin adjacent to trigeminal motoneurons.",
keywords = "Bone, Motoneuron, Neuromuscular, TMJ, Trigeminal",
author = "Byrd, {K. E.} and Sheskin, {T. A.}",
year = "2001",
month = "1",
day = "1",
doi = "10.1177/00220345010800081001",
language = "English (US)",
volume = "80",
pages = "1730--1735",
journal = "Journal of Dental Research",
issn = "0022-0345",
publisher = "SAGE Publications Inc.",
number = "8",

}

TY - JOUR

T1 - Effects of post-natal serotonin levels on craniofacial complex

AU - Byrd, K. E.

AU - Sheskin, T. A.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Although the role of serotonin (5-hydroxytryptamine or 5-HT) in pre-natal craniofacial growth and development has been studied, no research has been done on the effects of serotonin on post-natal craniofacial growth and development. The following experimental question was tested: What effect does increasing in vivo serotonin levels adjacent to trigeminal motoneurons have on post-natal craniofacial structures in young, actively growing rats? Forty male Sprague-Dawley rats were divided into 4 experimental groups (10% serotonin microspheres, 15% serotonin microspheres, blank microspheres, sham surgeries) and underwent stereotactic neuro-surgery at post-natal day 35; 5 rats of each group were killed at 14 and 21 post-surgical days for data collection. Statistical analyses by mixed-model, 4 × 2 repeated-measures ANOVA, and post hoc Fisher LSD tests revealed significant (P ≤ 0.05, 0.01) differences between groups and sides for muscle weight, cranial dimension, and TMJ dimension data. Data described here indicate that significant alterations of post-natal craniofacial structures can be caused by altered in vivo levels of serotonin adjacent to trigeminal motoneurons.

AB - Although the role of serotonin (5-hydroxytryptamine or 5-HT) in pre-natal craniofacial growth and development has been studied, no research has been done on the effects of serotonin on post-natal craniofacial growth and development. The following experimental question was tested: What effect does increasing in vivo serotonin levels adjacent to trigeminal motoneurons have on post-natal craniofacial structures in young, actively growing rats? Forty male Sprague-Dawley rats were divided into 4 experimental groups (10% serotonin microspheres, 15% serotonin microspheres, blank microspheres, sham surgeries) and underwent stereotactic neuro-surgery at post-natal day 35; 5 rats of each group were killed at 14 and 21 post-surgical days for data collection. Statistical analyses by mixed-model, 4 × 2 repeated-measures ANOVA, and post hoc Fisher LSD tests revealed significant (P ≤ 0.05, 0.01) differences between groups and sides for muscle weight, cranial dimension, and TMJ dimension data. Data described here indicate that significant alterations of post-natal craniofacial structures can be caused by altered in vivo levels of serotonin adjacent to trigeminal motoneurons.

KW - Bone

KW - Motoneuron

KW - Neuromuscular

KW - TMJ

KW - Trigeminal

UR - http://www.scopus.com/inward/record.url?scp=0034811413&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034811413&partnerID=8YFLogxK

U2 - 10.1177/00220345010800081001

DO - 10.1177/00220345010800081001

M3 - Article

C2 - 11669484

AN - SCOPUS:0034811413

VL - 80

SP - 1730

EP - 1735

JO - Journal of Dental Research

JF - Journal of Dental Research

SN - 0022-0345

IS - 8

ER -