Effects of pulmonary vein ablation on regional atrial vagal innervation and vulnerability to atrial fibrillation in dogs

Mehdi Razavi, Shulong Zhang, Donghui Yang, Robert A. Sanders, Biswajit Kar, Scott Delapasse, Tomohiko Ai, Wendel Moreira, Bari Olivier, Dirar S. Khoury, Jie Cheng

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Introduction: Pulmonary vein (PV) isolation has proven to be an effective therapy for atrial fibrillation (AF). However, clinical evidence suggests that suppression of AF after PV isolation could not be fully attributed to the interruption of electrical conduction in and out of the PVs. Furthermore, little is known regarding the effects of ablation around the PVs on the atrial electrophysiological properties. We aimed to study the changes in atrial response to vagal stimulation (VS) after PV ablation (PVA). Methods: We studied 11 adult mongrel dogs under general anesthesia. Bilateral cervical sympathovagal trunks were decentralized. Propranolol was given to block sympathetic effects. Multipolar catheters were placed into right atrial appendage (RAA), distal and proximal coronary sinus (CSD, CSP), and left atrial free wall (LAFW). PVA was performed via trans-septal approach. Atrial effective refractory period (AERP) and vulnerability window (VW) of AF were measured with and without VS before and after ablation to isolate the PVs. Results: After ablation, AERP shortening in response to VS significantly decreased in the left atrium (43.64 ± 21.57 vs 11.82 ± 9.82 msec, P <0.001 at LAFW; 50.91 ± 26.25 vs 11.82 ± 14.01 msec, P <0.001 at CSP; 50 ± 31.94 vs 17.27 ± 20.54 msec, P <0.005 at CSD), while the response to VS did not change significantly at RAA (58.18 ± 28.22 vs 50.91 ± 22.12 msec, P = 0.245). After ablation, atrial fibrillation VW during VS narrowed (20.63 ± 11.48 vs 5.63 ± 8.63 msec, P <0.03 at LAFW; 26.25 ± 12.46 vs 5.00 ± 9.64 msec, P = 0.001 at CSP; 28.75 ± 18.47 vs 6.88 ± 7.53 msec, P <0.02 at CSD, and 33.75 ± 24.5 vs 16.25 ± 9.91 msec, P = 0.03 at RAA). Conclusions: Ablation around the PV ostia diminishes left atrial response to VS and decreases the atrial VW. The attenuated vagal response after ablation may contribute to the suppression of AF.

Original languageEnglish (US)
Pages (from-to)879-884
Number of pages6
JournalJournal of Cardiovascular Electrophysiology
Volume16
Issue number8
DOIs
StatePublished - Aug 2005
Externally publishedYes

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Pulmonary Veins
Atrial Fibrillation
Atrial Appendage
Dogs
Coronary Sinus
Heart Atria
Propranolol
General Anesthesia
Catheters

Keywords

  • Ablation
  • Atrial fibrillation
  • Vagal denervation
  • Vulnerability window

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Effects of pulmonary vein ablation on regional atrial vagal innervation and vulnerability to atrial fibrillation in dogs. / Razavi, Mehdi; Zhang, Shulong; Yang, Donghui; Sanders, Robert A.; Kar, Biswajit; Delapasse, Scott; Ai, Tomohiko; Moreira, Wendel; Olivier, Bari; Khoury, Dirar S.; Cheng, Jie.

In: Journal of Cardiovascular Electrophysiology, Vol. 16, No. 8, 08.2005, p. 879-884.

Research output: Contribution to journalArticle

Razavi, M, Zhang, S, Yang, D, Sanders, RA, Kar, B, Delapasse, S, Ai, T, Moreira, W, Olivier, B, Khoury, DS & Cheng, J 2005, 'Effects of pulmonary vein ablation on regional atrial vagal innervation and vulnerability to atrial fibrillation in dogs', Journal of Cardiovascular Electrophysiology, vol. 16, no. 8, pp. 879-884. https://doi.org/10.1111/j.1540-8167.2005.50048.x
Razavi, Mehdi ; Zhang, Shulong ; Yang, Donghui ; Sanders, Robert A. ; Kar, Biswajit ; Delapasse, Scott ; Ai, Tomohiko ; Moreira, Wendel ; Olivier, Bari ; Khoury, Dirar S. ; Cheng, Jie. / Effects of pulmonary vein ablation on regional atrial vagal innervation and vulnerability to atrial fibrillation in dogs. In: Journal of Cardiovascular Electrophysiology. 2005 ; Vol. 16, No. 8. pp. 879-884.
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abstract = "Introduction: Pulmonary vein (PV) isolation has proven to be an effective therapy for atrial fibrillation (AF). However, clinical evidence suggests that suppression of AF after PV isolation could not be fully attributed to the interruption of electrical conduction in and out of the PVs. Furthermore, little is known regarding the effects of ablation around the PVs on the atrial electrophysiological properties. We aimed to study the changes in atrial response to vagal stimulation (VS) after PV ablation (PVA). Methods: We studied 11 adult mongrel dogs under general anesthesia. Bilateral cervical sympathovagal trunks were decentralized. Propranolol was given to block sympathetic effects. Multipolar catheters were placed into right atrial appendage (RAA), distal and proximal coronary sinus (CSD, CSP), and left atrial free wall (LAFW). PVA was performed via trans-septal approach. Atrial effective refractory period (AERP) and vulnerability window (VW) of AF were measured with and without VS before and after ablation to isolate the PVs. Results: After ablation, AERP shortening in response to VS significantly decreased in the left atrium (43.64 ± 21.57 vs 11.82 ± 9.82 msec, P <0.001 at LAFW; 50.91 ± 26.25 vs 11.82 ± 14.01 msec, P <0.001 at CSP; 50 ± 31.94 vs 17.27 ± 20.54 msec, P <0.005 at CSD), while the response to VS did not change significantly at RAA (58.18 ± 28.22 vs 50.91 ± 22.12 msec, P = 0.245). After ablation, atrial fibrillation VW during VS narrowed (20.63 ± 11.48 vs 5.63 ± 8.63 msec, P <0.03 at LAFW; 26.25 ± 12.46 vs 5.00 ± 9.64 msec, P = 0.001 at CSP; 28.75 ± 18.47 vs 6.88 ± 7.53 msec, P <0.02 at CSD, and 33.75 ± 24.5 vs 16.25 ± 9.91 msec, P = 0.03 at RAA). Conclusions: Ablation around the PV ostia diminishes left atrial response to VS and decreases the atrial VW. The attenuated vagal response after ablation may contribute to the suppression of AF.",
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author = "Mehdi Razavi and Shulong Zhang and Donghui Yang and Sanders, {Robert A.} and Biswajit Kar and Scott Delapasse and Tomohiko Ai and Wendel Moreira and Bari Olivier and Khoury, {Dirar S.} and Jie Cheng",
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T1 - Effects of pulmonary vein ablation on regional atrial vagal innervation and vulnerability to atrial fibrillation in dogs

AU - Razavi, Mehdi

AU - Zhang, Shulong

AU - Yang, Donghui

AU - Sanders, Robert A.

AU - Kar, Biswajit

AU - Delapasse, Scott

AU - Ai, Tomohiko

AU - Moreira, Wendel

AU - Olivier, Bari

AU - Khoury, Dirar S.

AU - Cheng, Jie

PY - 2005/8

Y1 - 2005/8

N2 - Introduction: Pulmonary vein (PV) isolation has proven to be an effective therapy for atrial fibrillation (AF). However, clinical evidence suggests that suppression of AF after PV isolation could not be fully attributed to the interruption of electrical conduction in and out of the PVs. Furthermore, little is known regarding the effects of ablation around the PVs on the atrial electrophysiological properties. We aimed to study the changes in atrial response to vagal stimulation (VS) after PV ablation (PVA). Methods: We studied 11 adult mongrel dogs under general anesthesia. Bilateral cervical sympathovagal trunks were decentralized. Propranolol was given to block sympathetic effects. Multipolar catheters were placed into right atrial appendage (RAA), distal and proximal coronary sinus (CSD, CSP), and left atrial free wall (LAFW). PVA was performed via trans-septal approach. Atrial effective refractory period (AERP) and vulnerability window (VW) of AF were measured with and without VS before and after ablation to isolate the PVs. Results: After ablation, AERP shortening in response to VS significantly decreased in the left atrium (43.64 ± 21.57 vs 11.82 ± 9.82 msec, P <0.001 at LAFW; 50.91 ± 26.25 vs 11.82 ± 14.01 msec, P <0.001 at CSP; 50 ± 31.94 vs 17.27 ± 20.54 msec, P <0.005 at CSD), while the response to VS did not change significantly at RAA (58.18 ± 28.22 vs 50.91 ± 22.12 msec, P = 0.245). After ablation, atrial fibrillation VW during VS narrowed (20.63 ± 11.48 vs 5.63 ± 8.63 msec, P <0.03 at LAFW; 26.25 ± 12.46 vs 5.00 ± 9.64 msec, P = 0.001 at CSP; 28.75 ± 18.47 vs 6.88 ± 7.53 msec, P <0.02 at CSD, and 33.75 ± 24.5 vs 16.25 ± 9.91 msec, P = 0.03 at RAA). Conclusions: Ablation around the PV ostia diminishes left atrial response to VS and decreases the atrial VW. The attenuated vagal response after ablation may contribute to the suppression of AF.

AB - Introduction: Pulmonary vein (PV) isolation has proven to be an effective therapy for atrial fibrillation (AF). However, clinical evidence suggests that suppression of AF after PV isolation could not be fully attributed to the interruption of electrical conduction in and out of the PVs. Furthermore, little is known regarding the effects of ablation around the PVs on the atrial electrophysiological properties. We aimed to study the changes in atrial response to vagal stimulation (VS) after PV ablation (PVA). Methods: We studied 11 adult mongrel dogs under general anesthesia. Bilateral cervical sympathovagal trunks were decentralized. Propranolol was given to block sympathetic effects. Multipolar catheters were placed into right atrial appendage (RAA), distal and proximal coronary sinus (CSD, CSP), and left atrial free wall (LAFW). PVA was performed via trans-septal approach. Atrial effective refractory period (AERP) and vulnerability window (VW) of AF were measured with and without VS before and after ablation to isolate the PVs. Results: After ablation, AERP shortening in response to VS significantly decreased in the left atrium (43.64 ± 21.57 vs 11.82 ± 9.82 msec, P <0.001 at LAFW; 50.91 ± 26.25 vs 11.82 ± 14.01 msec, P <0.001 at CSP; 50 ± 31.94 vs 17.27 ± 20.54 msec, P <0.005 at CSD), while the response to VS did not change significantly at RAA (58.18 ± 28.22 vs 50.91 ± 22.12 msec, P = 0.245). After ablation, atrial fibrillation VW during VS narrowed (20.63 ± 11.48 vs 5.63 ± 8.63 msec, P <0.03 at LAFW; 26.25 ± 12.46 vs 5.00 ± 9.64 msec, P = 0.001 at CSP; 28.75 ± 18.47 vs 6.88 ± 7.53 msec, P <0.02 at CSD, and 33.75 ± 24.5 vs 16.25 ± 9.91 msec, P = 0.03 at RAA). Conclusions: Ablation around the PV ostia diminishes left atrial response to VS and decreases the atrial VW. The attenuated vagal response after ablation may contribute to the suppression of AF.

KW - Ablation

KW - Atrial fibrillation

KW - Vagal denervation

KW - Vulnerability window

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