Effects of Race and Sex on Features of Eosinophilic Esophagitis

Fouad J. Moawad, Evan S. Dellon, Sami R. Achem, Tony Ljuldjuraj, Daniel J. Green, Corinne L. Maydonovitch, Diana R. Brizuela, Sandeep Gupta, Mirna Chehade

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background & Aims: Clinical and endoscopic features of eosinophilic esophagitis (EoE) differ between children and adults and among racial backgrounds. We investigated whether there were any associations between race or sex and clinical presentation, endoscopic features, and histologic findings from patients with EoE of various racial backgrounds. Methods: We performed a retrospective, multicenter, cross-sectional analysis of 793 patients with EoE (476 adults and 317 children; mean age, 26 years; range, 0.1-84 years; 72% male) from clinical registries at 5 tertiary care centers in the United States. EoE was defined per consensus guidelines. Data with predetermined variables were extracted from clinical registries at each participating institution. Results: Of the study cohort, 660 patients were white (83%), 77 were African American (10%), and 56 were of other races (7%). A significantly larger proportion of white persons than African Americans or other races had dysphagia (74%, 56%, and 53%, respectively; P <.001), food impaction (35%, 13%, and 13%, respectively; P <.001), and features of EoE that included rings (46%, 25%, and 18%, respectively; P <.001) or furrows (70%, 58%, and 55%, respectively; P = .012). Males and females had similar clinical presentations, histories of atopy, findings from endoscopy, and histologic characteristics. A higher proportion of males than females had strictures (17% vs 11%; P = .038). Conclusions: Race, and to a smaller degree sex, are associated with features of EoE. African Americans have different clinical symptoms and fewer endoscopic features of EoE than white persons. EoE should be considered in African Americans even without typical findings.

Original languageEnglish (US)
Pages (from-to)23-30
Number of pages8
JournalClinical Gastroenterology and Hepatology
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2016

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Eosinophilic Esophagitis
African Americans
Registries
Deglutition Disorders
Tertiary Care Centers
Endoscopy
Pathologic Constriction
Cohort Studies
Cross-Sectional Studies
Guidelines
Food

Keywords

  • Allergy
  • Eosinophilic Esophagitis
  • Epidemiology
  • Food
  • Race

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Moawad, F. J., Dellon, E. S., Achem, S. R., Ljuldjuraj, T., Green, D. J., Maydonovitch, C. L., ... Chehade, M. (2016). Effects of Race and Sex on Features of Eosinophilic Esophagitis. Clinical Gastroenterology and Hepatology, 14(1), 23-30. https://doi.org/10.1016/j.cgh.2015.08.034

Effects of Race and Sex on Features of Eosinophilic Esophagitis. / Moawad, Fouad J.; Dellon, Evan S.; Achem, Sami R.; Ljuldjuraj, Tony; Green, Daniel J.; Maydonovitch, Corinne L.; Brizuela, Diana R.; Gupta, Sandeep; Chehade, Mirna.

In: Clinical Gastroenterology and Hepatology, Vol. 14, No. 1, 01.01.2016, p. 23-30.

Research output: Contribution to journalArticle

Moawad, FJ, Dellon, ES, Achem, SR, Ljuldjuraj, T, Green, DJ, Maydonovitch, CL, Brizuela, DR, Gupta, S & Chehade, M 2016, 'Effects of Race and Sex on Features of Eosinophilic Esophagitis', Clinical Gastroenterology and Hepatology, vol. 14, no. 1, pp. 23-30. https://doi.org/10.1016/j.cgh.2015.08.034
Moawad FJ, Dellon ES, Achem SR, Ljuldjuraj T, Green DJ, Maydonovitch CL et al. Effects of Race and Sex on Features of Eosinophilic Esophagitis. Clinical Gastroenterology and Hepatology. 2016 Jan 1;14(1):23-30. https://doi.org/10.1016/j.cgh.2015.08.034
Moawad, Fouad J. ; Dellon, Evan S. ; Achem, Sami R. ; Ljuldjuraj, Tony ; Green, Daniel J. ; Maydonovitch, Corinne L. ; Brizuela, Diana R. ; Gupta, Sandeep ; Chehade, Mirna. / Effects of Race and Sex on Features of Eosinophilic Esophagitis. In: Clinical Gastroenterology and Hepatology. 2016 ; Vol. 14, No. 1. pp. 23-30.
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abstract = "Background & Aims: Clinical and endoscopic features of eosinophilic esophagitis (EoE) differ between children and adults and among racial backgrounds. We investigated whether there were any associations between race or sex and clinical presentation, endoscopic features, and histologic findings from patients with EoE of various racial backgrounds. Methods: We performed a retrospective, multicenter, cross-sectional analysis of 793 patients with EoE (476 adults and 317 children; mean age, 26 years; range, 0.1-84 years; 72{\%} male) from clinical registries at 5 tertiary care centers in the United States. EoE was defined per consensus guidelines. Data with predetermined variables were extracted from clinical registries at each participating institution. Results: Of the study cohort, 660 patients were white (83{\%}), 77 were African American (10{\%}), and 56 were of other races (7{\%}). A significantly larger proportion of white persons than African Americans or other races had dysphagia (74{\%}, 56{\%}, and 53{\%}, respectively; P <.001), food impaction (35{\%}, 13{\%}, and 13{\%}, respectively; P <.001), and features of EoE that included rings (46{\%}, 25{\%}, and 18{\%}, respectively; P <.001) or furrows (70{\%}, 58{\%}, and 55{\%}, respectively; P = .012). Males and females had similar clinical presentations, histories of atopy, findings from endoscopy, and histologic characteristics. A higher proportion of males than females had strictures (17{\%} vs 11{\%}; P = .038). Conclusions: Race, and to a smaller degree sex, are associated with features of EoE. African Americans have different clinical symptoms and fewer endoscopic features of EoE than white persons. EoE should be considered in African Americans even without typical findings.",
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