Effects of selective vagal and stellate ganglion stimulation on atrial refractoriness

Douglas P. Zipes, Michael J. Mihalick, Gordon T. Robbins

Research output: Contribution to journalArticle

Abstract

AUTHORS' SYNOPSIS: This study reports results of selective right and left vagosympathetic trunk (VST) and stellate ganglion stimulation (supra-maximal intensity) on atrial refractory period (ARP) in dogs. The effect of selective stellate stimulation on A-V conduction was also evaluated. During right and left VST stimulation, the region of the sinus node exhibited greater ARP shortening than most of the tested sites on the right atrium and all of the tested sites on the left atrium. The right VST exerted a greater effect on the right atrium than on the left atrium. Right VST stimulation shortened ARP at most tested right atrial sites more than did left VST stimulation. Selective vagal stimulation could result in three-fold difference in ARPs at the same electrode site. During right or left stellate ganglion stimulation, the refractory period change at any atrial site was usually minimal and often did not change at all. Supra-maximal right or left stellate stimulation shortened A-H (nodal) conduction by 50% or more in some experiments but shortened conduction time distal to the bundle of His by only 1 to 3 msec.

Original languageEnglish
Pages (from-to)647-655
Number of pages9
JournalCardiovascular Research
Volume8
Issue number5
DOIs
StatePublished - Sep 1974

Fingerprint

Stellate Ganglion
Heart Atria
Refractory materials
Conduction
Bundle of His
Sinoatrial Node
Threefolds
Electrode
Bundle
Electrodes
Dogs
Vertex of a graph
Experiment
Experiments
Dog
Node

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Effects of selective vagal and stellate ganglion stimulation on atrial refractoriness. / Zipes, Douglas P.; Mihalick, Michael J.; Robbins, Gordon T.

In: Cardiovascular Research, Vol. 8, No. 5, 09.1974, p. 647-655.

Research output: Contribution to journalArticle

Zipes, Douglas P. ; Mihalick, Michael J. ; Robbins, Gordon T. / Effects of selective vagal and stellate ganglion stimulation on atrial refractoriness. In: Cardiovascular Research. 1974 ; Vol. 8, No. 5. pp. 647-655.
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