Effects of Sodium Chloride on Prostacyclin-Stimulated Renin Release in Dogs with Filtering and Nonfiltering Kidneys

Daniel Villarreal, Ronald H. Freeman, James O. Davis, John R. Dietz, Stephen F. Echtenkamp

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The effects of intrarenal infusion of sodium chloride (NaCl) on prostacyclin (PGI2)-stimulated hyperreninemia were examined in groups of anesthetized dogs with either a single filtering kidney or a single denervated nonfiltering kidney, a model in which the renal tubules are damaged, and the macula densa is nonfunctional. After control observations, intrarenal infusion of prostacyclin at nonhypotensive doses resulted in significant increments of renin secretion and renal blood flow (RBF) in both preparations. Superimposition of intrarenal NaCl to the ongoing prostacyclin infusion produced a striking decrease of renin secretion in dogs with a filtering kidney. In contrast, dogs with a nonfiltering kidney failed to show a significant change in renin secretion during intrarenal NaCl administration. Renal blood flow remained unaffected by NaCl in both groups. The increment in renal venous plasma sodium concentration of 18-21 meq/liter was similar in both series. It is proposed that the renin response to intrarenal NaCl was mediated through the renal tubules, since renin secretion failed to decrease in the nonfiltering kidney preparation. Thus, the present results indicate that prostacyclin-stimulated renin secretion was modulated by a tubular mechanism, probably the macula densa.

Original languageEnglish (US)
Pages (from-to)34-40
Number of pages7
JournalProceedings of the Society for Experimental Biology and Medicine
Volume171
Issue number1
DOIs
StatePublished - Oct 1982
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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