Effects of statins on renal function

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Abstract

This report reviews data on the development of proteinuria in patients with chronic kidney disease who are treated with 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) for dyslipidemia. Although subgroup analyses of statin trials have shown cardiovascular benefits in subjects with chronic kidney disease, concern about statin-induced proteinuria remains high. Experimental studies have suggested that the proteinuria seen with statin treatment results from the inhibition of receptor-mediated endocytosis, the likely mechanism of protein uptake in proximal tubular cells. Transient proteinuria may signify little more than the effective inhibition of cholesterol synthesis at this site. The blockade of protein trafficking in tubular cells is thought to reduce inflammation, slow fibrosis, and diminish proteinuria in the long term. Post hoc analyses of large clinical trials in subjects without overt renal disease have generally supported this notion, showing that statins most benefit patients with the greatest baseline renal deficits. Statins have also been shown to preserve glomerular filtration rate and reduce proteinuria in subjects with nondiabetic renal disease. In conclusion, in the absence of prospective, randomized trials in renally impaired patients, the collective evidence indicates that statin therapy may slow the decrease in renal function that generally attends atherosclerotic disease. The incidence of proteinuria with potent statins is only 1% to 2% when these drugs are given in recommended doses. Several large trials are currently under way to examine the safety and efficacy of statins in renally compromised patients at high risk for cardiovascular disease.

Original languageEnglish
Pages (from-to)748-755
Number of pages8
JournalThe American Journal of Cardiology
Volume97
Issue number5
DOIs
StatePublished - Mar 1 2006

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Proteinuria
Kidney
Chronic Renal Insufficiency
Protein Transport
Dyslipidemias
Endocytosis
Glomerular Filtration Rate
Oxidoreductases
Fibrosis
Cardiovascular Diseases
Cholesterol
Clinical Trials
Inflammation
Safety

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effects of statins on renal function. / Agarwal, Rajiv.

In: The American Journal of Cardiology, Vol. 97, No. 5, 01.03.2006, p. 748-755.

Research output: Contribution to journalArticle

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