Effects of suppression of bone turnover on cortical and trabecular load sharing in the canine vertebral body

Senthil K. Eswaran, Grant Bevill, Prem Nagarathnam, Matthew Allen, David Burr, Tony M. Keaveny

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The relative biomechanical effects of antiresorptive treatment on cortical thickness vs. trabecular bone microarchitecture in the spine are not well understood. To address this, T-10 vertebral bodies were analyzed from skeletally mature female beagle dogs that had been treated with oral saline (n=8 control) or a high dose of oral risedronate (0.5 mg/kg/day, n=9 RIS-suppressed) for 1 year. Two linearly elastic finite element models (36-μm voxel size) were generated for each vertebral body-a whole-vertebra model and a trabecular-compartment model-and subjected to uniform compressive loading. Tissue-level material properties were kept constant to isolate the effects of changes in microstructure alone. Suppression of bone turnover resulted in increased stiffness of the whole vertebra (20.9%, p=0.02) and the trabecular compartment (26.0%, p=0.01), while the computed stiffness of the cortical shell (difference between whole-vertebra and trabecular-compartment stiffnesses, 11.7%, p=0.15) was statistically unaltered. Regression analyses indicated subtle but significant changes in the relative structural roles of the cortical shell and the trabecular compartment. Despite higher average cortical shell thickness in RIS-suppressed vertebrae (23.1%, p=0.002), the maximum load taken by the shell for a given value of shell mass fraction was lower (p=0.005) for the RIS-suppressed group. Taken together, our results suggest that-in this canine model-the overall changes in the compressive stiffness of the vertebral body due to suppression of bone turnover were attributable more to the changes in the trabecular compartment than in the cortical shell. Such biomechanical studies provide an unique insight into higher-scale effects such as the biomechanical responses of the whole vertebra.

Original languageEnglish
Pages (from-to)517-523
Number of pages7
JournalJournal of Biomechanics
Volume42
Issue number4
DOIs
StatePublished - Mar 11 2009

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Bone Remodeling
Canidae
Bone
Spine
Stiffness
Materials properties
Tissue
Microstructure
Regression Analysis
Dogs

Keywords

  • Antiresorptive treatment
  • Bone quality
  • Cortical shell
  • Load sharing
  • Microarchitecture
  • Suppressed bone turnover
  • Trabecular bone

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Rehabilitation
  • Biophysics
  • Biomedical Engineering

Cite this

Effects of suppression of bone turnover on cortical and trabecular load sharing in the canine vertebral body. / Eswaran, Senthil K.; Bevill, Grant; Nagarathnam, Prem; Allen, Matthew; Burr, David; Keaveny, Tony M.

In: Journal of Biomechanics, Vol. 42, No. 4, 11.03.2009, p. 517-523.

Research output: Contribution to journalArticle

Eswaran, Senthil K. ; Bevill, Grant ; Nagarathnam, Prem ; Allen, Matthew ; Burr, David ; Keaveny, Tony M. / Effects of suppression of bone turnover on cortical and trabecular load sharing in the canine vertebral body. In: Journal of Biomechanics. 2009 ; Vol. 42, No. 4. pp. 517-523.
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