Effects of the serotonin reuptake inhibitor fluvoxamine on yohimbine-induced anxiety in panic disorder

Andrew W. Goddard, Scott W. Woods, Diane E. Sholomskas, Wayne K. Goodman, Dennis S. Charney, George R. Heninger

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

To assess the effects of the selective serotonin reuptake blocker fluvoxamine on noradrenergic function in patients with panic disorder, an intravenous yohimbine challenge test was administered to eight patients with panic disorder before and after 8 weeks of fluvoxamine treatment and to a parallel group of eight patients treated with placebo. Fluvoxamine treatment reduced yohimbine-induced anxiety while placebo treatment had no effect on this variable. Both fluvoxamine and placebo treatment had little effect on biochemical or physiologic responses to yohombine.

Original languageEnglish (US)
Pages (from-to)119-133
Number of pages15
JournalPsychiatry Research
Volume48
Issue number2
DOIs
StatePublished - Aug 1993

Keywords

  • 3-methoxy-4-hydroxyphenylglycol
  • Norepinephrine
  • blood pressure
  • cortisol
  • heart rate

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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    Goddard, A. W., Woods, S. W., Sholomskas, D. E., Goodman, W. K., Charney, D. S., & Heninger, G. R. (1993). Effects of the serotonin reuptake inhibitor fluvoxamine on yohimbine-induced anxiety in panic disorder. Psychiatry Research, 48(2), 119-133. https://doi.org/10.1016/0165-1781(93)90036-G