Effects of timolol and dorzolamide on retrobulbar hemodynamics in patients with newly diagnosed primary open-angle glaucoma

Fernando Galassi, Andrea Sodi, Giulia Renieri, Francesca Ucci, Benedetta Pieri, Alon Harris, Brent Siesky

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

The authors considered a group of patients with newly diagnosed primary open-angle glaucoma studying the effects of a 4-week treatment with timolol or dorzolamide on retrobulbar vessels. Ocular hemodynamics were assessed by means of color Doppler imaging of the ophthalmic artery, the temporal short posterior ciliary arteries (SPCAs) and the central retinal artery. For each vessel, systolic and diastolic blood flow velocities were measured, and the resistivity index (RI) was calculated. The only significant result was a reduction of temporal SPCA RI after dorzolamide treatment in comparison with baseline (p =0.011). In the same group, dorzolamide treatment had a slight and nonsignificant increase in temporal SPCA diastolic velocity. The resistance decrease observed after dorzolamide treatment in the ciliary circulation may be due to the decrease in intraocular pressure or a possible direct vasodilating effect of the drug.

Original languageEnglish (US)
Pages (from-to)123-128
Number of pages6
JournalOphthalmologica
Volume216
Issue number2
DOIs
StatePublished - Apr 10 2002
Externally publishedYes

Keywords

  • Color Doppler imaging
  • Dorzolamide
  • Ocular hemodynamics
  • Primary open-angle glaucoma

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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