Effects of treadmill running in a rat model of chronic kidney disease

Jason Organ, Matthew Allen, A. Myers-White, W. Elkhatib, K. D. O'Neill, Xuening (Neal) Chen, Sharon Moe, K. G. Avin

Research output: Contribution to journalArticle

Abstract

Chronic kidney disease (CKD) progression results in musculoskeletal dysfunction that is associated with a higher likelihood of hospitalization and is predictive of hospitalizations and mortality. Despite this, there is a lack of effective interventions to treat the musculoskeletal dysfunction. We studied treadmill running as an intervention to improve musculoskeletal health in a translational rat model that has slowly progressive CKD. CKD rats were subjected to treadmill exercise or no treadmill exercise for 10 weeks (n = 8 each group). Animals ran for 60 min, 5 times per week starting at a speed of 8 m/min and ending at 18 m/min (1 m/min increase/week). Treadmill training had no effect on muscle strength (assessed as maximally stimulated torque), half-relaxation time (time from peak torque to 50%) or muscle cross-sectional area. Overall, there were no biochemical improvements related to CKD progression. Skeletal muscle catabolism was higher than non-exercised animals without a concomitant change in muscle synthesis markers or regeneration transcription factors. These results suggest that aerobic exercise, achieved via treadmill running was not protective in CKD animals and actually produced potentially harmful effects (increased catabolism). Given the high prevalence and dramatic musculoskeletal mobility impairment in patients with CKD, there is a clear need to understand how to effectively prescribe exercise in order to benefit the musculoskeletal system.

Original languageEnglish (US)
Pages (from-to)19-23
Number of pages5
JournalBiochemistry and Biophysics Reports
Volume16
DOIs
StatePublished - Dec 1 2018

Fingerprint

Exercise equipment
Chronic Renal Insufficiency
Running
Rats
Muscle
Exercise
Animals
Torque
Disease Progression
Hospitalization
Musculoskeletal system
Muscles
Musculoskeletal System
Muscle Strength
Relaxation time
Regeneration
Skeletal Muscle
Transcription Factors
Health
Mortality

Keywords

  • Chronic kidney disease
  • Sarcopenia
  • Skeletal muscle
  • Treadmill training

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Effects of treadmill running in a rat model of chronic kidney disease. / Organ, Jason; Allen, Matthew; Myers-White, A.; Elkhatib, W.; O'Neill, K. D.; Chen, Xuening (Neal); Moe, Sharon; Avin, K. G.

In: Biochemistry and Biophysics Reports, Vol. 16, 01.12.2018, p. 19-23.

Research output: Contribution to journalArticle

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