Effects of variations in renal function on the clinical pharmacology of bleomycin administered as an iv bolus

S. T. Crooke, R. L. Comis, L. H. Einhorn, J. E. Strong, A. Broughton, A. W. Prestayko

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

The clinical pharmacology of bleomycin administered as an i.v. bolus has been studied in a homogeneous group of patients receiving a single regimen containing bleomycin, vinblastine, and cis dichlorodiammineplatinum(II). These studies demonstrated that in patients with creatinine clearance ≥ 35 ml/min, the serum (or plasma) terminal elimination half life of bleomycin was approximately 115 min. In patients with creatinine clearances < 25-35 ml/min, the terminal elimination half life increased exponentially as the creatinine clearance decreased. The volume of distribution was approximately 20 l, and was unaffected by changes in the creatinine clearance. The microbiologic assay and radioimmunoassay employed gave equivalent results.

Original languageEnglish (US)
Pages (from-to)1631-1636
Number of pages6
JournalCancer Treatment Reports
Volume61
Issue number9
StatePublished - Dec 1 1977
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Effects of variations in renal function on the clinical pharmacology of bleomycin administered as an iv bolus'. Together they form a unique fingerprint.

  • Cite this

    Crooke, S. T., Comis, R. L., Einhorn, L. H., Strong, J. E., Broughton, A., & Prestayko, A. W. (1977). Effects of variations in renal function on the clinical pharmacology of bleomycin administered as an iv bolus. Cancer Treatment Reports, 61(9), 1631-1636.