Effects of vitamin D supplementation in older African American women

J. Christopher Gallagher, Munro Peacock, Vinod Yalamanchili, Lynette M. Smith

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Context: Serum 25-hydroxyvitamin D (25OHD) is lower in women with darker skin color. Is it due to lower skin production, lower absorption, or different metabolism of vitamin D? Objectives: The objective of the study was to measure the effect of vitamin D3 on serum 25OHD and serum PTH in older African American women with vitamin D insufficiency and the serum 25OHD 20 ng/mL or less (<50 nmol/L). The results can be used to estimate the Recommended Dietary Allowance (RDA). Design and Setting: This was a randomized, double-blind placebo trial at Creighton University Medical Center and Indiana University Medical Center. Participants: Participants were 110 healthy older African American women. Interventions: The intervention consisted of participants randomly assigned to placebo, vitamin D3 400, 800, 1600, 2400, 3200, 4000, or 4800 IU daily; calcium supplements were given to maintain total calcium intake of 1200-1400 mg/d. Main Outcome Measurements: Change in serum 25OHD and serum PTH levels at 12 months was measured. Results: Mean baseline serum 25OHD was 13 ng/mL (33 nmol/L). On 4800 IU, serum 25OHD averaged 50 ng/mL (125 nmol/L) compared with 47 ng/mL (117 nmol/L) in Caucasian women. Serum PTH at 12 months decreased significantly (P = .008) when related to serum 25OHD but not dose. Hypercalcemia occurred in 7% and hypercalciuria in 15%. Events were unrelated to vitamin D dose. Conclusion: Vitamin D3 800 IU increased serum 25OHD greater than 20 ng/mL (>50 nmol/L) in 97.5% of the African American women just as it did in the Caucasian women, and therefore, the RDA is the same for both groups. Because absorption and metabolism of oral vitamin D absorption is similar in both groups, lower levels of serum 25OHD in African Americans must be due to lower production of vitamin D in skin.

Original languageEnglish (US)
Pages (from-to)1137-1146
Number of pages10
JournalJournal of Clinical Endocrinology and Metabolism
Volume98
Issue number3
DOIs
StatePublished - Mar 1 2013

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Vitamin D
African Americans
Skin
Serum
Metabolism
Cholecalciferol
Skin Pigmentation
Color

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Effects of vitamin D supplementation in older African American women. / Gallagher, J. Christopher; Peacock, Munro; Yalamanchili, Vinod; Smith, Lynette M.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 98, No. 3, 01.03.2013, p. 1137-1146.

Research output: Contribution to journalArticle

Gallagher, J. Christopher ; Peacock, Munro ; Yalamanchili, Vinod ; Smith, Lynette M. / Effects of vitamin D supplementation in older African American women. In: Journal of Clinical Endocrinology and Metabolism. 2013 ; Vol. 98, No. 3. pp. 1137-1146.
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abstract = "Context: Serum 25-hydroxyvitamin D (25OHD) is lower in women with darker skin color. Is it due to lower skin production, lower absorption, or different metabolism of vitamin D? Objectives: The objective of the study was to measure the effect of vitamin D3 on serum 25OHD and serum PTH in older African American women with vitamin D insufficiency and the serum 25OHD 20 ng/mL or less (<50 nmol/L). The results can be used to estimate the Recommended Dietary Allowance (RDA). Design and Setting: This was a randomized, double-blind placebo trial at Creighton University Medical Center and Indiana University Medical Center. Participants: Participants were 110 healthy older African American women. Interventions: The intervention consisted of participants randomly assigned to placebo, vitamin D3 400, 800, 1600, 2400, 3200, 4000, or 4800 IU daily; calcium supplements were given to maintain total calcium intake of 1200-1400 mg/d. Main Outcome Measurements: Change in serum 25OHD and serum PTH levels at 12 months was measured. Results: Mean baseline serum 25OHD was 13 ng/mL (33 nmol/L). On 4800 IU, serum 25OHD averaged 50 ng/mL (125 nmol/L) compared with 47 ng/mL (117 nmol/L) in Caucasian women. Serum PTH at 12 months decreased significantly (P = .008) when related to serum 25OHD but not dose. Hypercalcemia occurred in 7{\%} and hypercalciuria in 15{\%}. Events were unrelated to vitamin D dose. Conclusion: Vitamin D3 800 IU increased serum 25OHD greater than 20 ng/mL (>50 nmol/L) in 97.5{\%} of the African American women just as it did in the Caucasian women, and therefore, the RDA is the same for both groups. Because absorption and metabolism of oral vitamin D absorption is similar in both groups, lower levels of serum 25OHD in African Americans must be due to lower production of vitamin D in skin.",
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