Effects of x-irradiation on the levels of glutamate, aspartate and GABA in different regions of the cerebellum of the rat

M. A. Rea, W. J. McBride

Research output: Contribution to journalArticle

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Abstract

The effect of the x-irradiation-induced loss of cerebellar granule and stellate cells on the levels of glutamate, aspartate and GABA in regions of the rat cerebellum was determined. The level of glutamate was significantly lower in the neuron-depleted cerebellar cortex while GABA levels were higher than control values in the cerebellar cortex and white matter of the x-irradiated rats. Aspartate levels were not changed by x-irradiation in any cerebellar region. The data is discussed in terms of the proposed role of glutamate as the excitatory neurotransmitter released from granule cells.

Original languageEnglish
Pages (from-to)2355-2359
Number of pages5
JournalLife Sciences
Volume23
Issue number24
DOIs
StatePublished - Dec 11 1978

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Aspartic Acid
Cerebellum
gamma-Aminobutyric Acid
Rats
Glutamic Acid
Cerebellar Cortex
Irradiation
Neurons
Neurotransmitter Agents

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of x-irradiation on the levels of glutamate, aspartate and GABA in different regions of the cerebellum of the rat. / Rea, M. A.; McBride, W. J.

In: Life Sciences, Vol. 23, No. 24, 11.12.1978, p. 2355-2359.

Research output: Contribution to journalArticle

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