Effects of zidovudine and stavudine on mitochondrial DNA of differentiating 3T3-F442a cells are not associated with imbalanced deoxynucleotide pools

Matthew D. Lynx, Darcy D. Laclair, Edward E. McKee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

To test whether zidovudine (3′-azido-3′-deoxythymidine) (AZT) inhibition of thymidine phosphorylation causes depletion of the TTP pool resulting in mitochondrial DNA depletion, 3T3-F442a cells were differentiated in the presence of AZT and analyzed to determine mitochondrial DNA content and deoxynucleotide levels. These results suggest that AZT toxicity may not be related to deoxynucleotide pool alterations.

Original languageEnglish
Pages (from-to)1252-1255
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume53
Issue number3
DOIs
StatePublished - Mar 2009

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Stavudine
3T3 Cells
Zidovudine
Mitochondrial DNA
Thymidine
Phosphorylation
thymidine 5'-triphosphate

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

Effects of zidovudine and stavudine on mitochondrial DNA of differentiating 3T3-F442a cells are not associated with imbalanced deoxynucleotide pools. / Lynx, Matthew D.; Laclair, Darcy D.; McKee, Edward E.

In: Antimicrobial Agents and Chemotherapy, Vol. 53, No. 3, 03.2009, p. 1252-1255.

Research output: Contribution to journalArticle

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