Efferent projections of the infralimbic cortex of the rat

K. M. Hurley, H. Herbert, Margaret Moga, C. B. Saper

Research output: Contribution to journalArticle

583 Citations (Scopus)

Abstract

On the basis of stimulation studies, it has been proposed that the infralimbic cortex (ILC), Brodmann area 25, may serve as an autonomic motor cortex. To explore this hypothesis, we have combined anterograde tracing with Phaseolus vulgaris leucoagglutinin (PHA-L) and retrograde tracing with wheat germ aggutinin conjugated to horseradish peroxidase (WGA-HRP) to determine the efferent projections from the ILC. Axons exit the ILC in one of three efferent pathways. The dorsal pathway ascends through layers III and V to innervate the prelimbic and anterior cingulate cortices. The lateral pathway courses through the nucleus accumbens to innervate the insular cortex, the perirhinal cortex, and parts of the piriform cortex. In addition, some fibers from the lateral pathway enter the corticospinal tract. The ventral pathway is by far the largest and innervates the thalamus (including the paraventricular nucleus of the thalamus, the border zone between the paraventricular and medial dorsal nuclei, and the paratenial, reuniens, ventromedial, parafasicular, and subparafasicular nuclei), the hypothalamus (including the lateral hypothalamic and medial preoptic areas, and the suprachiasmatic, dorsomedial, and supramammillary nuclei), the amygdala (including the central, medial, and basomedial nuclei, and the periamygdaloid cortex) and the bed nucleus of the stria terminalis. The ventral efferent pathway also provides descending projections to autonomic cell groups of the brainstem and spinal cord including the periaqueductal gray matter, the parabrachial nucleus, the nucleus of the solitary tract, the dorsal motor vagal nucleus, the nucleus ambiguus, and the ventrolateral medulla, as well as lamina I and the intermediolateral column of the spinal cord. The ILC has extensive projections to central autonomic nuclei that may subserve a role in modulating visceral responses to emotional stimuli, such as stress.

Original languageEnglish (US)
Pages (from-to)249-276
Number of pages28
JournalJournal of Comparative Neurology
Volume308
Issue number2
StatePublished - 1991
Externally publishedYes

Fingerprint

Midline Thalamic Nuclei
Mediodorsal Thalamic Nucleus
Efferent Pathways
Preoptic Area
Spinal Cord
Intralaminar Thalamic Nuclei
Posterior Hypothalamus
Septal Nuclei
Periaqueductal Gray
Medulla Oblongata
Pyramidal Tracts
Suprachiasmatic Nucleus
Solitary Nucleus
Gyrus Cinguli
Nucleus Accumbens
Motor Cortex
Horseradish Peroxidase
Amygdala
Thalamus
Cerebral Cortex

Keywords

  • amygdala
  • autonomic regulation
  • hypothalamus nucleus of the solitary tract
  • medial prefrontal cortex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hurley, K. M., Herbert, H., Moga, M., & Saper, C. B. (1991). Efferent projections of the infralimbic cortex of the rat. Journal of Comparative Neurology, 308(2), 249-276.

Efferent projections of the infralimbic cortex of the rat. / Hurley, K. M.; Herbert, H.; Moga, Margaret; Saper, C. B.

In: Journal of Comparative Neurology, Vol. 308, No. 2, 1991, p. 249-276.

Research output: Contribution to journalArticle

Hurley, KM, Herbert, H, Moga, M & Saper, CB 1991, 'Efferent projections of the infralimbic cortex of the rat', Journal of Comparative Neurology, vol. 308, no. 2, pp. 249-276.
Hurley, K. M. ; Herbert, H. ; Moga, Margaret ; Saper, C. B. / Efferent projections of the infralimbic cortex of the rat. In: Journal of Comparative Neurology. 1991 ; Vol. 308, No. 2. pp. 249-276.
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