Efficacy model for antibody-mediated pre-erythrocytic malaria vaccines

Michael T. White, Jamie T. Griffin, Eleanor M. Riley, Chris J. Drakeley, Ann M. Moorman, Peter Odada Sumba, James W. Kazura, Azra C. Ghani, Chandy C. John

Research output: Contribution to journalArticle

13 Scopus citations


Antibodies to the pre-erythrocytic antigens, circumsporozoite protein (CSP), thrombospondin-related adhesive protein (TRAP) and liver-stage antigen 1, have been measured in field studies of semiimmune adults and shown to correlate with protection from Plasmodium falciparum infection. A mathematical model is formulated to estimate the probability of sporozoite infection as a function of antibody titres to multiple pre-erythrocytic antigens. The variation in antibody titres from field data was used to estimate the relationship between the probability of P. falciparum infection per infectious mosquito bite and antibody titre. Using this relationship, we predict the effect of vaccinations that boost baseline CSP or TRAP antibody titres. Assuming the estimated relationship applies to vaccineinduced antibody titres, then single-component CSP or TRAP antibody-mediated pre-erythrocytic vaccines are likely to provide partial protection from infection, with vaccine efficacy of approximately 50 per cent depending on the magnitude of the vaccine-induced boost to antibody titres. It is possible that the addition of a TRAP component to a CSP-based vaccine such as RTS,S would provide an increase in infection-blocking efficacy of approximately 25 per cent should the problem of immunological interference between antigens be overcome.

Original languageEnglish (US)
Pages (from-to)1298-1305
Number of pages8
JournalProceedings of the Royal Society B: Biological Sciences
Issue number1710
StatePublished - Jan 1 2011
Externally publishedYes


  • Antibody
  • Malaria
  • Sporozoite
  • Vaccine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

Fingerprint Dive into the research topics of 'Efficacy model for antibody-mediated pre-erythrocytic malaria vaccines'. Together they form a unique fingerprint.

  • Cite this

    White, M. T., Griffin, J. T., Riley, E. M., Drakeley, C. J., Moorman, A. M., Sumba, P. O., Kazura, J. W., Ghani, A. C., & John, C. C. (2011). Efficacy model for antibody-mediated pre-erythrocytic malaria vaccines. Proceedings of the Royal Society B: Biological Sciences, 278(1710), 1298-1305. https://doi.org/10.1098/rspb.2010.1697