Efficacy of cevimeline vs. pilocarpine in the secretion of saliva: A pilot study

Jae Brimhall, Malhar A. Jhaveri, Juan F. Yepes

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Objectives To determine the efficacy and compare the side-effects of cevimeline and pilocarpine in the secretion of saliva in patients with xerostomia. Methods A randomized, cross-over, double blind study was designed. Fifteen patients with diagnosis of xerostomia were assigned to take either 5 mg of pilocarpine or 30 mg of cevimeline three times a day for four weeks. Salivary flow rates were measured during the initial baseline, first and second month appointments. Statistical analysis was carried out with ANOVA and post hoc t-tests. Results Twelve patients completed both medication treatments. Although both medications proved to increase salivary secretion, there was no significant difference between pilocarpine and cevimeline. Also, the perceived side-effects between the two medications were similar. Conclusion Both medications increased the secretion of saliva at the end of four weeks. However, there was a slightly higher increment in saliva with pilocarpine. However, the difference was not statistically significant.

Original languageEnglish (US)
Pages (from-to)123-127
Number of pages5
JournalSpecial Care in Dentistry
Issue number3
StatePublished - May 1 2013
Externally publishedYes


  • cevimeline
  • dry mouth
  • pilocarpine
  • xerostomia

ASJC Scopus subject areas

  • Dentistry(all)

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