Efficacy of infliximab in extrapulmonary sarcoidosis: Results from a randomised trial

M. A. Judson, R. P. Baughman, U. Costabel, S. Flavin, K. H. Lo, M. S. Kavuru, M. Drent, D. A. Culver, G. S. Davis, C. M. Fogarty, G. W. Hunninghake, A. S. Teirstein, M. Mandel, D. McNally, L. Tanoue, L. Newman, Y. Wasfi, H. Patrick, M. D. Rossman, G. RaghuO. Sharma, D. Wilkes, H. Yeager, J. F. Donahue, M. Kaye, N. Sweiss, N. Vetter, M. Thomeer, M. Brutsche, L. Nicod, D. Valeyre, P. Chanez, C. Albera, J. Grutters, H. Hoogsteden, J. Muller-Quernheim, R. Bonnet, F. Kanniess

Research output: Contribution to journalArticle

208 Scopus citations

Abstract

The aim of the present study was to investigate the efficacy of infliximab for the treatment of extrapulmonary sarcoidosis. A prospective, randomised, double-blind, placebo-controlled trial was conducted, with infliximab at 3 and 5 mg·kg-1 body weight administered over 24 weeks. Extrapulmonary organ severity was determined by a novel severity tool (extrapulmonary physician organ severity tool; ePOST) with an adjustment for the number of organs involved (ePOSTadj). In total, 138 patients enrolled in the trial of infliximab versus placebo for the treatment of chronic corticosteroid-dependent pulmonary sarcoidosis. The baseline severity of extrapulmonary organ involvement, as measured by ePOST, was similar across treatment groups. After 24 weeks of drug-therapy study, the change from baseline to week 24 in ePOST was greater for the combined infliximab group compared with the placebo group. After adjustment for the number of extrapulmonary organs involved, the improvement in ePOSTadj observed in the combined infliximab group was also greater than that observed in placebo-treated patients, after 24 weeks of therapy. The improvements in ePOST and ePOSTadj were not maintained during a subsequent 24-week washout period. Infliximab may be beneficial compared with placebo in the treatment of extrapulmonary sarcoidosis in patients already receiving corticosteroids, as assessed by the severity tool described in the present study. Copyright

Original languageEnglish (US)
Pages (from-to)1189-1196
Number of pages8
JournalEuropean Respiratory Journal
Volume31
Issue number6
DOIs
StatePublished - Jun 2008

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Keywords

  • Extrathoracic
  • Infliximab
  • Sarcoidosis
  • Severity
  • Therapy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Medicine(all)

Cite this

Judson, M. A., Baughman, R. P., Costabel, U., Flavin, S., Lo, K. H., Kavuru, M. S., Drent, M., Culver, D. A., Davis, G. S., Fogarty, C. M., Hunninghake, G. W., Teirstein, A. S., Mandel, M., McNally, D., Tanoue, L., Newman, L., Wasfi, Y., Patrick, H., Rossman, M. D., ... Kanniess, F. (2008). Efficacy of infliximab in extrapulmonary sarcoidosis: Results from a randomised trial. European Respiratory Journal, 31(6), 1189-1196. https://doi.org/10.1183/09031936.00051907