Efficacy of oral tolvaptan in acute heart failure patients with hypotension and renal impairment

Muthiah Vaduganathan, Mihai Gheorghiade, Peter Pang, Marvin A. Konstam, Faiez Zannad, Karl Swedberg, Liliana Grinfeld, John C. Burnett, Holly B. Krasa, Christopher Zimmer, John Blair, John Ouyang, Aldo P. Maggioni

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

AIMS: Although congestion is the main reason for admission in patients with worsening acute heart failure syndromes, patients presenting with low SBP and renal impairment often do not respond adequately to and may not tolerate traditional diuretic therapy. We sought to determine the short-term hemodynamic effects of tolvaptan in this high-risk population. METHODS: In a subset analysis of the Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study with Tolvaptan trial, 759 patients (18% of total) had elevated blood urea nitrogen (BUN) (>20mg/dl) and low SBP (

Original languageEnglish (US)
Pages (from-to)415-422
Number of pages8
JournalJournal of Cardiovascular Medicine
Volume13
Issue number7
DOIs
StatePublished - Jul 2012
Externally publishedYes

Fingerprint

Hypotension
Heart Failure
Kidney
Patient Admission
Blood Urea Nitrogen
Vasopressins
Diuretics
Hemodynamics
Outcome Assessment (Health Care)
Population
tolvaptan
Therapeutics

Keywords

  • acute heart failure
  • hemodynamics
  • hypotension
  • renal failure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Vaduganathan, M., Gheorghiade, M., Pang, P., Konstam, M. A., Zannad, F., Swedberg, K., ... Maggioni, A. P. (2012). Efficacy of oral tolvaptan in acute heart failure patients with hypotension and renal impairment. Journal of Cardiovascular Medicine, 13(7), 415-422. https://doi.org/10.2459/JCM.0b013e328355a740

Efficacy of oral tolvaptan in acute heart failure patients with hypotension and renal impairment. / Vaduganathan, Muthiah; Gheorghiade, Mihai; Pang, Peter; Konstam, Marvin A.; Zannad, Faiez; Swedberg, Karl; Grinfeld, Liliana; Burnett, John C.; Krasa, Holly B.; Zimmer, Christopher; Blair, John; Ouyang, John; Maggioni, Aldo P.

In: Journal of Cardiovascular Medicine, Vol. 13, No. 7, 07.2012, p. 415-422.

Research output: Contribution to journalArticle

Vaduganathan, M, Gheorghiade, M, Pang, P, Konstam, MA, Zannad, F, Swedberg, K, Grinfeld, L, Burnett, JC, Krasa, HB, Zimmer, C, Blair, J, Ouyang, J & Maggioni, AP 2012, 'Efficacy of oral tolvaptan in acute heart failure patients with hypotension and renal impairment', Journal of Cardiovascular Medicine, vol. 13, no. 7, pp. 415-422. https://doi.org/10.2459/JCM.0b013e328355a740
Vaduganathan, Muthiah ; Gheorghiade, Mihai ; Pang, Peter ; Konstam, Marvin A. ; Zannad, Faiez ; Swedberg, Karl ; Grinfeld, Liliana ; Burnett, John C. ; Krasa, Holly B. ; Zimmer, Christopher ; Blair, John ; Ouyang, John ; Maggioni, Aldo P. / Efficacy of oral tolvaptan in acute heart failure patients with hypotension and renal impairment. In: Journal of Cardiovascular Medicine. 2012 ; Vol. 13, No. 7. pp. 415-422.
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