Efficacy of yoga for vasomotor symptoms: A randomized controlled trial

Katherine M. Newton, Susan D. Reed, Katherine A. Guthrie, Karen J. Sherman, Cathryn Booth-Laforce, Bette Caan, Barbara Sternfeld, Janet Carpenter, Lee A. Learman, Ellen W. Freeman, Lee S. Cohen, Hadine Joffe, Garnet L. Anderson, Joseph C. Larson, Julie R. Hunt, Kristine E. Ensrud, Andrea Z. Lacroix

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

OBJECTIVE: This study aims to determine the efficacy of yoga in alleviating vasomotor symptoms (VMS) frequency and bother. METHODS: This study was a three-by-two factorial, randomized controlled trial. Eligible women were randomized to yoga (n = 107), exercise (n = 106), or usual activity (n = 142), and were simultaneously randomized to a double-blind comparison of ω-3 fatty acid (n = 177) or placebo (n = 178) capsules. Yoga intervention consisted of 12 weekly 90-minute yoga classes with daily home practice. Primary outcomes were VMS frequency and bother assessed by daily diaries at baseline, 6 weeks, and 12 weeks. Secondary outcomes included insomnia symptoms (Insomnia Severity Index) at baseline and 12 weeks. RESULTS: Among 249 randomized women, 237 (95%) completed 12-week assessments. The mean baseline VMS frequency was 7.4 per day (95% CI, 6.6 to 8.1) in the yoga group and 8.0 per day (95% CI, 7.3 to 8.7) in the usual activity group. Intent-to-treat analyses included all participants with response data (n = 237). There was no difference between intervention groups in the change in VMS frequency from baseline to 6 and 12 weeks (mean difference [yoga-usual activity] from baseline at 6 wk,-0.3 [95% CI,-1.1 to 0.5]; mean difference [yoga-usual activity] from baseline at 12 wk,-0.3 [95% CI,-1.2 to 0.6]; P = 0.119 across both time points). Results were similar for VMS bother. At week 12, yoga was associated with an improvement in insomnia symptoms (mean difference [yoga-usual activity] in the change in Insomnia Severity Index, 1.3 [95% CI,-2.5 to-0.1]; P = 0.007). CONCLUSIONS: Among healthy women, 12 weeks of yoga class plus home practice, compared with usual activity, do not improve VMS frequency or bother but reduce insomnia symptoms.

Original languageEnglish
Pages (from-to)339-346
Number of pages8
JournalMenopause
Volume21
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Yoga
Randomized Controlled Trials
Sleep Initiation and Maintenance Disorders
Capsules
Fatty Acids
Placebos
Exercise

Keywords

  • Clinical Trials Network
  • Hot flashes
  • Meditation
  • Menopause
  • Vasomotor symptoms
  • Yoga

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Medicine(all)

Cite this

Newton, K. M., Reed, S. D., Guthrie, K. A., Sherman, K. J., Booth-Laforce, C., Caan, B., ... Lacroix, A. Z. (2014). Efficacy of yoga for vasomotor symptoms: A randomized controlled trial. Menopause, 21(4), 339-346. https://doi.org/10.1097/GME.0b013e31829e4baa

Efficacy of yoga for vasomotor symptoms : A randomized controlled trial. / Newton, Katherine M.; Reed, Susan D.; Guthrie, Katherine A.; Sherman, Karen J.; Booth-Laforce, Cathryn; Caan, Bette; Sternfeld, Barbara; Carpenter, Janet; Learman, Lee A.; Freeman, Ellen W.; Cohen, Lee S.; Joffe, Hadine; Anderson, Garnet L.; Larson, Joseph C.; Hunt, Julie R.; Ensrud, Kristine E.; Lacroix, Andrea Z.

In: Menopause, Vol. 21, No. 4, 2014, p. 339-346.

Research output: Contribution to journalArticle

Newton, KM, Reed, SD, Guthrie, KA, Sherman, KJ, Booth-Laforce, C, Caan, B, Sternfeld, B, Carpenter, J, Learman, LA, Freeman, EW, Cohen, LS, Joffe, H, Anderson, GL, Larson, JC, Hunt, JR, Ensrud, KE & Lacroix, AZ 2014, 'Efficacy of yoga for vasomotor symptoms: A randomized controlled trial', Menopause, vol. 21, no. 4, pp. 339-346. https://doi.org/10.1097/GME.0b013e31829e4baa
Newton KM, Reed SD, Guthrie KA, Sherman KJ, Booth-Laforce C, Caan B et al. Efficacy of yoga for vasomotor symptoms: A randomized controlled trial. Menopause. 2014;21(4):339-346. https://doi.org/10.1097/GME.0b013e31829e4baa
Newton, Katherine M. ; Reed, Susan D. ; Guthrie, Katherine A. ; Sherman, Karen J. ; Booth-Laforce, Cathryn ; Caan, Bette ; Sternfeld, Barbara ; Carpenter, Janet ; Learman, Lee A. ; Freeman, Ellen W. ; Cohen, Lee S. ; Joffe, Hadine ; Anderson, Garnet L. ; Larson, Joseph C. ; Hunt, Julie R. ; Ensrud, Kristine E. ; Lacroix, Andrea Z. / Efficacy of yoga for vasomotor symptoms : A randomized controlled trial. In: Menopause. 2014 ; Vol. 21, No. 4. pp. 339-346.
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abstract = "OBJECTIVE: This study aims to determine the efficacy of yoga in alleviating vasomotor symptoms (VMS) frequency and bother. METHODS: This study was a three-by-two factorial, randomized controlled trial. Eligible women were randomized to yoga (n = 107), exercise (n = 106), or usual activity (n = 142), and were simultaneously randomized to a double-blind comparison of ω-3 fatty acid (n = 177) or placebo (n = 178) capsules. Yoga intervention consisted of 12 weekly 90-minute yoga classes with daily home practice. Primary outcomes were VMS frequency and bother assessed by daily diaries at baseline, 6 weeks, and 12 weeks. Secondary outcomes included insomnia symptoms (Insomnia Severity Index) at baseline and 12 weeks. RESULTS: Among 249 randomized women, 237 (95{\%}) completed 12-week assessments. The mean baseline VMS frequency was 7.4 per day (95{\%} CI, 6.6 to 8.1) in the yoga group and 8.0 per day (95{\%} CI, 7.3 to 8.7) in the usual activity group. Intent-to-treat analyses included all participants with response data (n = 237). There was no difference between intervention groups in the change in VMS frequency from baseline to 6 and 12 weeks (mean difference [yoga-usual activity] from baseline at 6 wk,-0.3 [95{\%} CI,-1.1 to 0.5]; mean difference [yoga-usual activity] from baseline at 12 wk,-0.3 [95{\%} CI,-1.2 to 0.6]; P = 0.119 across both time points). Results were similar for VMS bother. At week 12, yoga was associated with an improvement in insomnia symptoms (mean difference [yoga-usual activity] in the change in Insomnia Severity Index, 1.3 [95{\%} CI,-2.5 to-0.1]; P = 0.007). CONCLUSIONS: Among healthy women, 12 weeks of yoga class plus home practice, compared with usual activity, do not improve VMS frequency or bother but reduce insomnia symptoms.",
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AU - Newton, Katherine M.

AU - Reed, Susan D.

AU - Guthrie, Katherine A.

AU - Sherman, Karen J.

AU - Booth-Laforce, Cathryn

AU - Caan, Bette

AU - Sternfeld, Barbara

AU - Carpenter, Janet

AU - Learman, Lee A.

AU - Freeman, Ellen W.

AU - Cohen, Lee S.

AU - Joffe, Hadine

AU - Anderson, Garnet L.

AU - Larson, Joseph C.

AU - Hunt, Julie R.

AU - Ensrud, Kristine E.

AU - Lacroix, Andrea Z.

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N2 - OBJECTIVE: This study aims to determine the efficacy of yoga in alleviating vasomotor symptoms (VMS) frequency and bother. METHODS: This study was a three-by-two factorial, randomized controlled trial. Eligible women were randomized to yoga (n = 107), exercise (n = 106), or usual activity (n = 142), and were simultaneously randomized to a double-blind comparison of ω-3 fatty acid (n = 177) or placebo (n = 178) capsules. Yoga intervention consisted of 12 weekly 90-minute yoga classes with daily home practice. Primary outcomes were VMS frequency and bother assessed by daily diaries at baseline, 6 weeks, and 12 weeks. Secondary outcomes included insomnia symptoms (Insomnia Severity Index) at baseline and 12 weeks. RESULTS: Among 249 randomized women, 237 (95%) completed 12-week assessments. The mean baseline VMS frequency was 7.4 per day (95% CI, 6.6 to 8.1) in the yoga group and 8.0 per day (95% CI, 7.3 to 8.7) in the usual activity group. Intent-to-treat analyses included all participants with response data (n = 237). There was no difference between intervention groups in the change in VMS frequency from baseline to 6 and 12 weeks (mean difference [yoga-usual activity] from baseline at 6 wk,-0.3 [95% CI,-1.1 to 0.5]; mean difference [yoga-usual activity] from baseline at 12 wk,-0.3 [95% CI,-1.2 to 0.6]; P = 0.119 across both time points). Results were similar for VMS bother. At week 12, yoga was associated with an improvement in insomnia symptoms (mean difference [yoga-usual activity] in the change in Insomnia Severity Index, 1.3 [95% CI,-2.5 to-0.1]; P = 0.007). CONCLUSIONS: Among healthy women, 12 weeks of yoga class plus home practice, compared with usual activity, do not improve VMS frequency or bother but reduce insomnia symptoms.

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