Efficient allocation of patients to treatment cells in clinical trials with more than two treatment conditions

Scott W. Woods, Diane E. Sholomskas, M. Katherine Shear, Jack M. Gorman, David H. Barlow, Andrew W. Goddard, Jacob Cohen

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: Clinical trials generally allocate patients to equal-sized treatment groups. The authors propose that it may be more efficient to allocate unequal proportions of the total sample size to treatments when more than two treatments are being compared. Method: This proposal is illustrated with two examples. One involved a comparison of three treatments and used a dichotomous categorical outcome. The other involved comparison of three treatments and used a continuous measure. Results: In both examples, a considerable increase in efficiency was realized by reducing the number of patients assigned to the placebo cell. Conclusions: Unequal allocation of patients to treatments should be considered when more than two groups are compared.

Original languageEnglish (US)
Pages (from-to)1446-1448
Number of pages3
JournalAmerican Journal of Psychiatry
Volume155
Issue number10
StatePublished - Oct 1998
Externally publishedYes

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Clinical Trials
Therapeutics
Sample Size
Placebos

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Woods, S. W., Sholomskas, D. E., Shear, M. K., Gorman, J. M., Barlow, D. H., Goddard, A. W., & Cohen, J. (1998). Efficient allocation of patients to treatment cells in clinical trials with more than two treatment conditions. American Journal of Psychiatry, 155(10), 1446-1448.

Efficient allocation of patients to treatment cells in clinical trials with more than two treatment conditions. / Woods, Scott W.; Sholomskas, Diane E.; Shear, M. Katherine; Gorman, Jack M.; Barlow, David H.; Goddard, Andrew W.; Cohen, Jacob.

In: American Journal of Psychiatry, Vol. 155, No. 10, 10.1998, p. 1446-1448.

Research output: Contribution to journalArticle

Woods, SW, Sholomskas, DE, Shear, MK, Gorman, JM, Barlow, DH, Goddard, AW & Cohen, J 1998, 'Efficient allocation of patients to treatment cells in clinical trials with more than two treatment conditions', American Journal of Psychiatry, vol. 155, no. 10, pp. 1446-1448.
Woods SW, Sholomskas DE, Shear MK, Gorman JM, Barlow DH, Goddard AW et al. Efficient allocation of patients to treatment cells in clinical trials with more than two treatment conditions. American Journal of Psychiatry. 1998 Oct;155(10):1446-1448.
Woods, Scott W. ; Sholomskas, Diane E. ; Shear, M. Katherine ; Gorman, Jack M. ; Barlow, David H. ; Goddard, Andrew W. ; Cohen, Jacob. / Efficient allocation of patients to treatment cells in clinical trials with more than two treatment conditions. In: American Journal of Psychiatry. 1998 ; Vol. 155, No. 10. pp. 1446-1448.
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