EIF3 regulation of protein synthesis, tumorigenesis, and therapeutic response

Ji Ye Yin, Zizheng Dong, Jian-Ting Zhang

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Translation initiation is the rate-limiting step of protein synthesis and highly regulated. Eukaryotic initiation factor 3 (eIF3) is the largest and most complex initiation factor consisting of 13 putative subunits. A growing number of studies suggest that eIF3 and its subunits may represent a new group of protooncogenes and associates with prognosis. They regulate translation of a subset of mRNAs involved in many cellular processes including proliferation, apoptosis, DNA repair, and cell cycle. Therefore, unveiling the mechanisms of eIF3 action in tumorigenesis may help identify attractive targets for cancer therapy. Here, we describe a series of methods used in the study of eIF3 function in regulating protein synthesis, tumorigenesis, and cellular response to therapeutic treatments.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages113-127
Number of pages15
Volume1507
DOIs
StatePublished - 2017

Publication series

NameMethods in Molecular Biology
Volume1507
ISSN (Print)10643745

Fingerprint

Eukaryotic Initiation Factor-3
Carcinogenesis
Proteins
Peptide Initiation Factors
Therapeutics
DNA Repair
Cell Cycle
Apoptosis
Messenger RNA
Neoplasms

Keywords

  • Eukaryotic initiation factor 3 (eIF3)
  • Protein synthesis
  • Therapeutic response
  • Translational control
  • Tumorigenesis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Yin, J. Y., Dong, Z., & Zhang, J-T. (2017). EIF3 regulation of protein synthesis, tumorigenesis, and therapeutic response. In Methods in Molecular Biology (Vol. 1507, pp. 113-127). (Methods in Molecular Biology; Vol. 1507). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-6518-2_9

EIF3 regulation of protein synthesis, tumorigenesis, and therapeutic response. / Yin, Ji Ye; Dong, Zizheng; Zhang, Jian-Ting.

Methods in Molecular Biology. Vol. 1507 Humana Press Inc., 2017. p. 113-127 (Methods in Molecular Biology; Vol. 1507).

Research output: Chapter in Book/Report/Conference proceedingChapter

Yin, JY, Dong, Z & Zhang, J-T 2017, EIF3 regulation of protein synthesis, tumorigenesis, and therapeutic response. in Methods in Molecular Biology. vol. 1507, Methods in Molecular Biology, vol. 1507, Humana Press Inc., pp. 113-127. https://doi.org/10.1007/978-1-4939-6518-2_9
Yin JY, Dong Z, Zhang J-T. EIF3 regulation of protein synthesis, tumorigenesis, and therapeutic response. In Methods in Molecular Biology. Vol. 1507. Humana Press Inc. 2017. p. 113-127. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-6518-2_9
Yin, Ji Ye ; Dong, Zizheng ; Zhang, Jian-Ting. / EIF3 regulation of protein synthesis, tumorigenesis, and therapeutic response. Methods in Molecular Biology. Vol. 1507 Humana Press Inc., 2017. pp. 113-127 (Methods in Molecular Biology).
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