EIF3 regulation of protein synthesis, tumorigenesis, and therapeutic response

Ji Ye Yin, Zizheng Dong, Jian Ting Zhang

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Translation initiation is the rate-limiting step of protein synthesis and highly regulated. Eukaryotic initiation factor 3 (eIF3) is the largest and most complex initiation factor consisting of 13 putative subunits. A growing number of studies suggest that eIF3 and its subunits may represent a new group of protooncogenes and associates with prognosis. They regulate translation of a subset of mRNAs involved in many cellular processes including proliferation, apoptosis, DNA repair, and cell cycle. Therefore, unveiling the mechanisms of eIF3 action in tumorigenesis may help identify attractive targets for cancer therapy. Here, we describe a series of methods used in the study of eIF3 function in regulating protein synthesis, tumorigenesis, and cellular response to therapeutic treatments.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages113-127
Number of pages15
DOIs
StatePublished - Jan 1 2017

Publication series

NameMethods in Molecular Biology
Volume1507
ISSN (Print)1064-3745

Keywords

  • Eukaryotic initiation factor 3 (eIF3)
  • Protein synthesis
  • Therapeutic response
  • Translational control
  • Tumorigenesis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    Yin, J. Y., Dong, Z., & Zhang, J. T. (2017). EIF3 regulation of protein synthesis, tumorigenesis, and therapeutic response. In Methods in Molecular Biology (pp. 113-127). (Methods in Molecular Biology; Vol. 1507). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-6518-2_9