Elafin is a biomarker of graft-versus-host disease of the skin

Sophie Paczesny, Thomas M. Braun, John E. Levine, Jason Hogan, Jeffrey Crawford, Bryan Coffing, Stephen Olsen, Sung W. Choi, Hong Wang, Vitor Faca, Sharon Pitteri, Qing Zhang, Alice Chin, Carrie Kitko, Shin Mineishi, Gregory Yanik, Edward Peres, David Hanauer, Ying Wang, Pavan ReddySamir Hanash, James L M Ferrara

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

Graft-versus-host disease (GVHD), the major complication of allogeneic bone marrow transplantation, affects the skin, liver, and gastrointestinal tract. There are no plasma biomarkers specific for any acute GVHD target organ. We used a large-scale quantitative proteomic discovery procedure to identify biomarker candidates of skin GVHD and validated the lead candidate, elafin, with enzyme-linked immunosorbent assay in samples from 492 patients. Elafin was overexpressed in GVHD skin biopsies. Plasma concentrations of elafin were significantly higher at the onset of skin GVHD, correlated with the eventual maximum grade of GVHD, and were associated with a greater risk of death relative to other known risk factors (hazard ratio, 1.78). We conclude that elafin has significant diagnostic and prognostic value as a biomarker of skin GVHD.

Original languageEnglish (US)
JournalScience Translational Medicine
Volume2
Issue number13
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Elafin
Graft vs Host Disease
Biomarkers
Skin
Homologous Transplantation
Bone Marrow Transplantation
Proteomics
Gastrointestinal Tract
Enzyme-Linked Immunosorbent Assay
Biopsy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Paczesny, S., Braun, T. M., Levine, J. E., Hogan, J., Crawford, J., Coffing, B., ... Ferrara, J. L. M. (2010). Elafin is a biomarker of graft-versus-host disease of the skin. Science Translational Medicine, 2(13). https://doi.org/10.1126/scitranslmed.3000406

Elafin is a biomarker of graft-versus-host disease of the skin. / Paczesny, Sophie; Braun, Thomas M.; Levine, John E.; Hogan, Jason; Crawford, Jeffrey; Coffing, Bryan; Olsen, Stephen; Choi, Sung W.; Wang, Hong; Faca, Vitor; Pitteri, Sharon; Zhang, Qing; Chin, Alice; Kitko, Carrie; Mineishi, Shin; Yanik, Gregory; Peres, Edward; Hanauer, David; Wang, Ying; Reddy, Pavan; Hanash, Samir; Ferrara, James L M.

In: Science Translational Medicine, Vol. 2, No. 13, 2010.

Research output: Contribution to journalArticle

Paczesny, S, Braun, TM, Levine, JE, Hogan, J, Crawford, J, Coffing, B, Olsen, S, Choi, SW, Wang, H, Faca, V, Pitteri, S, Zhang, Q, Chin, A, Kitko, C, Mineishi, S, Yanik, G, Peres, E, Hanauer, D, Wang, Y, Reddy, P, Hanash, S & Ferrara, JLM 2010, 'Elafin is a biomarker of graft-versus-host disease of the skin', Science Translational Medicine, vol. 2, no. 13. https://doi.org/10.1126/scitranslmed.3000406
Paczesny, Sophie ; Braun, Thomas M. ; Levine, John E. ; Hogan, Jason ; Crawford, Jeffrey ; Coffing, Bryan ; Olsen, Stephen ; Choi, Sung W. ; Wang, Hong ; Faca, Vitor ; Pitteri, Sharon ; Zhang, Qing ; Chin, Alice ; Kitko, Carrie ; Mineishi, Shin ; Yanik, Gregory ; Peres, Edward ; Hanauer, David ; Wang, Ying ; Reddy, Pavan ; Hanash, Samir ; Ferrara, James L M. / Elafin is a biomarker of graft-versus-host disease of the skin. In: Science Translational Medicine. 2010 ; Vol. 2, No. 13.
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