Electrical restitution and cardiac fibrillation

James N. Weiss, Peng Sheng Chen, Zhilin Qu, Hrayr S. Karagueuzian, Shin Fong Lin, Alan Garfinkel

Research output: Contribution to journalReview article

59 Scopus citations


Combined experimental and theoretical work has shown that restitution properties of the cardiac action potential duration and conduction velocity contribute to breakup of reentrant wavefronts during cardiac fibrillation independent of preexisting electrophysiologic heterogeneities in the tissue. Developing therapies that favorably alter these cardiac electrical restitution properties are a promising new approach to preventing fibrillation.

Original languageEnglish (US)
Pages (from-to)292-295
Number of pages4
JournalJournal of Cardiovascular Electrophysiology
Issue number3
StatePublished - Jan 1 2002
Externally publishedYes


  • Arrhythmias
  • Electrophysiology
  • Fibrillation
  • Restitution
  • Sudden cardiac death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Weiss, J. N., Chen, P. S., Qu, Z., Karagueuzian, H. S., Lin, S. F., & Garfinkel, A. (2002). Electrical restitution and cardiac fibrillation. Journal of Cardiovascular Electrophysiology, 13(3), 292-295. https://doi.org/10.1046/j.1540-8167.2002.00292.x